Brain repair after stroke - A novel neurological model

Steven L. Small, Giovanni Buccino, Ana Solodkin

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Following stroke, patients are commonly left with debilitating motor and speech impairments. This article reviews the state of the art in neurological repair for stroke and proposes a new model for the future. We suggest that stroke treatment - from the time of the ictus itself to living with the consequences - must be fundamentally neurological, from limiting the extent of injury at the outset, to repairing the consequent damage. Our model links brain and behaviour by targeting brain circuits, and we illustrate the model though action observation treatment, which aims to enhance brain network connectivity. The model is based on the assumptions that the mechanisms of neural repair inherently involve cellular and circuit plasticity, that brain plasticity is a synaptic phenomenon that is largely stimulus-dependent, and that brain repair required both physical and behavioural interventions that are tailored to reorganize specific brain circuits. We review current approaches to brain repair after stroke and present our new model, and discuss the biological foundations, rationales, and data to support our novel approach to upper-extremity and language rehabilitation. We believe that by enhancing plasticity at the level of brain network interactions, this neurological model for brain repair could ultimately lead to a cure for stroke.

Original languageEnglish (US)
Pages (from-to)698-707
Number of pages10
JournalNature Reviews Neurology
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Neurological Models
Stroke
Brain
Biological Models
Upper Extremity
Language
Rehabilitation
Observation

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Brain repair after stroke - A novel neurological model. / Small, Steven L.; Buccino, Giovanni; Solodkin, Ana.

In: Nature Reviews Neurology, Vol. 9, No. 12, 01.12.2013, p. 698-707.

Research output: Contribution to journalReview article

Small, Steven L. ; Buccino, Giovanni ; Solodkin, Ana. / Brain repair after stroke - A novel neurological model. In: Nature Reviews Neurology. 2013 ; Vol. 9, No. 12. pp. 698-707.
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