TY - JOUR
T1 - Brain structural abnormalities in emotional regulation and sensory processing regions associated with anxious depression
AU - Peng, Wei
AU - Jia, Zhiyun
AU - Huang, Xiaoqi
AU - Lui, Su
AU - Kuang, Weihong
AU - Sweeney, John A.
AU - Gong, Qiyong
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (Grant Nos. 81571637, 81771812 and 81820108018 ),the Sichuan Science and Technology Program ( 2018SZ0391 ), the Innovation Spark Project of Sichuan University (No. 2019SCUH0003 ), and the Program for Changjiang Scholars and Innovative Research Team in University of China (PCSIRT, Grant No. IRT16R52 ).
Funding Information:
Dr. Peng would like to thank the help from her colleagues in Huaxi MR Research Center (HMRRC) at West China Hospital of Sichuan University. She would also like to express her appreciation for the support from Dr. Bing Ming, the director of radiology department at People's Hospital of Deyang. This study was supported by the National Natural Science Foundation of China (Grant Nos. 81571637, 81771812 and 81820108018),the Sichuan Science and Technology Program (2018SZ0391), the Innovation Spark Project of Sichuan University (No. 2019SCUH0003), and the Program for Changjiang Scholars and Innovative Research Team in University of China (PCSIRT, Grant No. IRT16R52). W.K. and Q.G. conceptualized the project. Z.J. W.K. and W.P. designed the protocol. W.P. and Z.J. wrote the main manuscript text. W.P. Z.J. X.H. S.L. J.S. and W.K. performed the experiments. W.P. and Z.J. conducted the statistical analyses. All authors reviewed the findings, interpretation and final manuscript. This study was approved by the Clinical Trials and Biomedical Ethics Committee of Sichuan University, and written informed consent was obtained from each participant. This work has been carried out in accordance with Declaration of Helsinki.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/8/30
Y1 - 2019/8/30
N2 - Background: Considerable patients with major depressive disorder (MDD) comorbid with anxious symptoms, referred as anxious depression. The neural structural basis of this MDD specifier remains largely unknown. Methods: 104 patients with anxious depression, 57 MDD patients without significant anxious symptoms, and 160 healthy controls from single research center participated in the study with age and sex well-matched. We investigated gray matter alterations in anxious and non-anxious depression, explored different brain alterations between these two patient groups, and possible relationships between brain structural parameter and clinical information in patients. Results: Gray matter volumes differed in the right inferior frontal gyrus, right orbital frontal gyrus, left postcentral gyrus, bilateral culmen and left cuneus among the three groups. Anxious depression had smaller gray matter volumes in the right inferior frontal gyrus and orbital frontal gyrus relative to both non-anxious depression and healthy controls. Patients with anxious depression presented larger gray matter volumes in the left postcentral gyrus than non-anxious depression, and larger gray matter volumes in the left cuneus than healthy controls. In addition, both patient groups showed larger gray matter volumes in bilateral culmen relative to healthy controls. Gray matter volumes in the left postcentral gyrus were positively associated with overall depression severity and anxiety factor scores in anxious depression. Conclusion: Our study revealed brain structural abnormalities in emotional regulation and sensory processing regions of anxious depression, which may suggested distinct neurobiological mechanisms of this MDD specifier and could help explain different clinical manifestations in anxious depression from pure depression.
AB - Background: Considerable patients with major depressive disorder (MDD) comorbid with anxious symptoms, referred as anxious depression. The neural structural basis of this MDD specifier remains largely unknown. Methods: 104 patients with anxious depression, 57 MDD patients without significant anxious symptoms, and 160 healthy controls from single research center participated in the study with age and sex well-matched. We investigated gray matter alterations in anxious and non-anxious depression, explored different brain alterations between these two patient groups, and possible relationships between brain structural parameter and clinical information in patients. Results: Gray matter volumes differed in the right inferior frontal gyrus, right orbital frontal gyrus, left postcentral gyrus, bilateral culmen and left cuneus among the three groups. Anxious depression had smaller gray matter volumes in the right inferior frontal gyrus and orbital frontal gyrus relative to both non-anxious depression and healthy controls. Patients with anxious depression presented larger gray matter volumes in the left postcentral gyrus than non-anxious depression, and larger gray matter volumes in the left cuneus than healthy controls. In addition, both patient groups showed larger gray matter volumes in bilateral culmen relative to healthy controls. Gray matter volumes in the left postcentral gyrus were positively associated with overall depression severity and anxiety factor scores in anxious depression. Conclusion: Our study revealed brain structural abnormalities in emotional regulation and sensory processing regions of anxious depression, which may suggested distinct neurobiological mechanisms of this MDD specifier and could help explain different clinical manifestations in anxious depression from pure depression.
KW - Anxious depression
KW - Emotional regulation
KW - Gray matter
KW - Non-anxious depression
KW - Sensory processing
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U2 - 10.1016/j.pnpbp.2019.109676
DO - 10.1016/j.pnpbp.2019.109676
M3 - Article
C2 - 31226395
AN - SCOPUS:85067605787
SN - 0278-5846
VL - 94
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
M1 - 109676
ER -