Brains, Genes, and Primates

Juan Carlos Izpisua Belmonte, Edward M. Callaway, Patricia Churchland, Sarah J. Caddick, Guoping Feng, Gregg E. Homanics, Kuo Fen Lee, David A. Leopold, Cory T. Miller, Jude F. Mitchell, Shoukhrat Mitalipov, Alysson R. Moutri, J. Anthony Movshon, Hideyuki Okano, John H. Reynolds, Dario Ringach, Terrence J. Sejnowski, Afonso C. Silva, Peter L. Strick, Jun WuFeng Zhang

Research output: Contribution to journalReview article

122 Scopus citations

Abstract

One of the great strengths of the mouse model is the wide array of genetic tools that have been developed. Striking examples include methods for directed modification of the genome, and for regulated expression or inactivation of genes. Within neuroscience, it is now routine to express reporter genes, neuronal activity indicators, and opsins in specific neuronal types in the mouse. However, there are considerable anatomical, physiological, cognitive, and behavioral differences between the mouse and the human that, in some areas of inquiry, limit the degree to which insights derived from the mouse can be applied to understanding human neurobiology. Several recent advances have now brought into reach the goal of applying these tools to understanding the primate brain. Here we describe these advances, consider their potential to advance our understanding of the human brain and brain disorders, discuss bioethical considerations, and describe what will be needed to move forward. Recent advances have brought into reach the goal of applying genetic tools to understanding the primate brain. Reynolds and colleagues describe these advances, their potential to deepen understanding of the human brain, and what will be needed to move forward.

Original languageEnglish (US)
Pages (from-to)617-631
Number of pages15
JournalNeuron
Volume86
Issue number3
DOIs
StatePublished - May 6 2015
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    Izpisua Belmonte, J. C., Callaway, E. M., Churchland, P., Caddick, S. J., Feng, G., Homanics, G. E., Lee, K. F., Leopold, D. A., Miller, C. T., Mitchell, J. F., Mitalipov, S., Moutri, A. R., Movshon, J. A., Okano, H., Reynolds, J. H., Ringach, D., Sejnowski, T. J., Silva, A. C., Strick, P. L., ... Zhang, F. (2015). Brains, Genes, and Primates. Neuron, 86(3), 617-631. https://doi.org/10.1016/j.neuron.2015.03.021