Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents

W. Shirangi Fernando, André F. Martins, Piyu Zhao, Yunkou Wu, Garry E. Kiefer, Carlos Platas-Iglesias, A. Dean Sherry

Research output: Contribution to journalArticle

17 Scopus citations


EuDOTA-tetraamide complexes as paraCEST agents offer an attractive platform for designing biological sensors and responsive agents. The early versions of these agents showed low sensitivity at temperature and power levels suitable for in vivo applications partly due to non-optimal water exchange rates. Here we report two new EuDOTA derivatives having glutamyl-phosphonate side arms that display the slowest water exchange rates of any other paraCEST agent reported so far. The advantages of such systems are demonstrated experimentally both in vitro and in vivo and DFT calculations were performed to help understand the physical-chemical reasons for this interesting behavior.

Original languageEnglish (US)
Pages (from-to)3007-3014
Number of pages8
JournalInorganic Chemistry
Issue number6
StatePublished - Mar 21 2016


ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry

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