TY - JOUR
T1 - Breakthroughs in medicine and bioimaging with up-conversion nanoparticles
AU - Rostami, Iman
AU - Alanagh, Hamideh Rezvani
AU - Hu, Zhiyuan
AU - Shahmoradian, Sarah H.
N1 - Funding Information:
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No 701647.
Publisher Copyright:
© 2019 Rostami et al.
PY - 2019
Y1 - 2019
N2 - Nanomedicine is a medical application of biochemistry incorporated with materials chemistry at the scale of nanometer for the purpose of diagnosis, prevention, and treatment. New models and approaches are typically associated with nanomedicine for precise multifunctional diagnostic systems at molecular level. Hence, employing nanoparticles (NPs) has unveiled new opportunities for efficient therapies and remedy of difficult-to-cure diseases. Among all types of inorganic NPs, lanthanide-doped up-conversion nanoparticles (UCNPs) have shown excellent potential for biomedical applications, especially for multimodal bioimaging including fluorescence and electron microscopy. Association of these visualization techniques plus the capability for transporting biomaterials and drugs make them superior agents in the field of nanomedicine. Accordingly, in this review, we firstly presented a fundamental understanding of physical and optical properties of UCNPs and secondly, we illustrated some of the prominent associations with bioimaging, theranostics, cancer therapy, and optogenetics.
AB - Nanomedicine is a medical application of biochemistry incorporated with materials chemistry at the scale of nanometer for the purpose of diagnosis, prevention, and treatment. New models and approaches are typically associated with nanomedicine for precise multifunctional diagnostic systems at molecular level. Hence, employing nanoparticles (NPs) has unveiled new opportunities for efficient therapies and remedy of difficult-to-cure diseases. Among all types of inorganic NPs, lanthanide-doped up-conversion nanoparticles (UCNPs) have shown excellent potential for biomedical applications, especially for multimodal bioimaging including fluorescence and electron microscopy. Association of these visualization techniques plus the capability for transporting biomaterials and drugs make them superior agents in the field of nanomedicine. Accordingly, in this review, we firstly presented a fundamental understanding of physical and optical properties of UCNPs and secondly, we illustrated some of the prominent associations with bioimaging, theranostics, cancer therapy, and optogenetics.
KW - Bioimaging
KW - Theranostics
KW - Therapy
KW - Up-conversion nanoparticles
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U2 - 10.2147/IJN.S221433
DO - 10.2147/IJN.S221433
M3 - Article
C2 - 31576121
AN - SCOPUS:85072847663
SN - 1176-9114
VL - 14
SP - 7759
EP - 7780
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
ER -