TY - JOUR
T1 - Breast cancer in men
T2 - Aspects of familial aggregation
AU - Rosenblatt, Karin A.
AU - Thomas, David B.
AU - Mctiernan, Anne
AU - Austin, Melissa A.
AU - Stalsberg, Helge
AU - Stemhagen, Annette
AU - Thompson, W. Douglas
AU - Curnen, Mary G.Mccrea
AU - Satariano, William
AU - Austin, Donald F.
AU - Isacson, Peter
AU - Greenberg, Raymond S.
AU - Key, Charles
AU - Kolonel, Laurence
AU - West, Dee
N1 - Funding Information:
Received October 9, 1990; revised February 28, 1991; accepted March 14, 1991. Supported by Public Health Service (PHS) grant CA-35653 and by PHS training grant CA-09168 (K. A. Rosenblatt) from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services. K. A. Rosenblatt, D. B. Thomas, A. McTieman, M. A. Austin, Fred Hutchinson Cancer Research Center, Seattle, Wash. K. A. Rosenblatt, D. B. Thomas, M. A. Austin, University of Washington School of Public Health and Community Medicine, Seattle, Wash. H. Stalsberg, University of Tromso, Tromso, Norway. A. Stemhagen, State of New Jersey, Department of Health, Trenton, NJ. W. D. Thompson, Department of Applied Medical Sciences, University of South Maine, Portland, Maine. M. G. M. Curnen, Department of Epidemiology and Public Health, Yale University, School of Medicine, New Haven, Conn. W. Satariano, Michigan Cancer Foundation, Detroit, Mich. D. F. Austin, Resource for Cancer Epidemiology, Department of Health Services, Emeryville, Calif. P. Isacson, State Health Registry of Iowa, University of Iowa, Iowa City, Iowa. R. S. Greenberg, Department of Epidemiology and Biostatistics, Emory University, Atlanta, Ga. C. Key, New Mexico Tumor Registry, Albuquerque, NM. L. Kolonel, Epidemiology Program, Cancer Research Center of Hawaii, Honolulu, Hawaii. D. West, Northern California Cancer Center, Alameda, Calif. We acknowledge the assistance provided by Dr Suresh Moolgavkar in reviewing this manuscript and Dr Barbara McKnight in helping with the analysis. *Correspondcncc to: David B. Thomas, MD, Program in Epidemiology, MP-474, Fred Hutchinson Cancer Research Center, 1124 Columbia St, Seattle, WA 98104.
PY - 1991/6/19
Y1 - 1991/6/19
N2 - Familial aggregation of breast cancer in males was investigated in a population-based case-control study. Cases were ascertained from 10 Surveillance, Epidemiology, and End Results Program registries in the United States between 1983 and 1986. Controls were identified by random-digit dialing and from lists of Medicare recipients. The relative odds of developing breast cancer were similar in men with affected paternal and maternal relatives and in men with affected mothers and sisters. The risk increased with the number of affected relatives. The relative odds of developing breast cancer were greater in men with first-degree relatives who developed their mammary neoplasm before the age of 45 than in men with older first-degree affected relatives; the enhancement of risk in men with an affected sister was greater in those under age 60 than in older men. These results are similar to those observed by others in studies of breast cancer in women. [J Natl Cancer Inst 83:849-854, 1991].
AB - Familial aggregation of breast cancer in males was investigated in a population-based case-control study. Cases were ascertained from 10 Surveillance, Epidemiology, and End Results Program registries in the United States between 1983 and 1986. Controls were identified by random-digit dialing and from lists of Medicare recipients. The relative odds of developing breast cancer were similar in men with affected paternal and maternal relatives and in men with affected mothers and sisters. The risk increased with the number of affected relatives. The relative odds of developing breast cancer were greater in men with first-degree relatives who developed their mammary neoplasm before the age of 45 than in men with older first-degree affected relatives; the enhancement of risk in men with an affected sister was greater in those under age 60 than in older men. These results are similar to those observed by others in studies of breast cancer in women. [J Natl Cancer Inst 83:849-854, 1991].
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U2 - 10.1093/jnci/83.12.849
DO - 10.1093/jnci/83.12.849
M3 - Article
C2 - 2061945
AN - SCOPUS:0025809739
SN - 0027-8874
VL - 83
SP - 849
EP - 854
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 12
ER -