Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case–control and case–case analyses

Melanie Ruszczyk, Gary Zirpoli, Shicha Kumar, Elisa V. Bandera, Dana H. Bovbjerg, Lina Jandorf, Thaer Khoury, Helena Hwang, Gregory Ciupak, Karen Pawlish, Pepper Schedin, Patricia Masso-Welch, Christine B. Ambrosone, Chi Chen Hong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Invasive ductal carcinoma (IDC) is diagnosed with or without a ductal carcinoma in situ (DCIS) component. Previous analyses have found significant differences in tumor characteristics between pure IDC lacking DCIS and mixed IDC with DCIS. We will test our hypothesis that pure IDC represents a form of breast cancer with etiology and risk factors distinct from mixed IDC/DCIS. Methods: We compared reproductive risk factors for breast cancer risk, as well as family and smoking history between 831 women with mixed IDC/DCIS (n = 650) or pure IDC (n = 181), and 1,620 controls, in the context of the Women’s Circle of Health Study (WCHS), a case–control study of breast cancer in African-American and European-American women. Data on reproductive and lifestyle factors were collected during interviews, and tumor characteristics were abstracted from pathology reports. Case–control and case–case analyses were conducted using unconditional logistic regression. Results: Most risk factors were similarly associated with pure IDC and mixed IDC/DCIS. However, among postmenopausal women, risk of pure IDC was lower in women with body mass index (BMI) 25 to

Original languageEnglish (US)
Pages (from-to)183-198
Number of pages16
JournalCancer Causes and Control
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2016

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Ductal Carcinoma
Carcinoma in Situ
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Women's Health
African Americans
Life Style
Neoplasms
Body Mass Index
Logistic Models
Smoking
History
Interviews
Pathology

Keywords

  • Breast cancer
  • Cancer etiology
  • Cancer pathology
  • Ductal carcinoma in situ component
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case–control and case–case analyses. / Ruszczyk, Melanie; Zirpoli, Gary; Kumar, Shicha; Bandera, Elisa V.; Bovbjerg, Dana H.; Jandorf, Lina; Khoury, Thaer; Hwang, Helena; Ciupak, Gregory; Pawlish, Karen; Schedin, Pepper; Masso-Welch, Patricia; Ambrosone, Christine B.; Hong, Chi Chen.

In: Cancer Causes and Control, Vol. 27, No. 2, 01.02.2016, p. 183-198.

Research output: Contribution to journalArticle

Ruszczyk, M, Zirpoli, G, Kumar, S, Bandera, EV, Bovbjerg, DH, Jandorf, L, Khoury, T, Hwang, H, Ciupak, G, Pawlish, K, Schedin, P, Masso-Welch, P, Ambrosone, CB & Hong, CC 2016, 'Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case–control and case–case analyses', Cancer Causes and Control, vol. 27, no. 2, pp. 183-198. https://doi.org/10.1007/s10552-015-0696-z
Ruszczyk, Melanie ; Zirpoli, Gary ; Kumar, Shicha ; Bandera, Elisa V. ; Bovbjerg, Dana H. ; Jandorf, Lina ; Khoury, Thaer ; Hwang, Helena ; Ciupak, Gregory ; Pawlish, Karen ; Schedin, Pepper ; Masso-Welch, Patricia ; Ambrosone, Christine B. ; Hong, Chi Chen. / Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case–control and case–case analyses. In: Cancer Causes and Control. 2016 ; Vol. 27, No. 2. pp. 183-198.
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