Breast cancer with skeletal metastases at initial diagnosis

Distinctive clinical characteristics and favorable prognosis

M. M. Sherry, F. A. Greco, D. H. Johnson, J. D. Hainsworth

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Fifteen patients with breast cancer who had skeletal metastases already present at the time the primary breast lesion was detected, were retrospectively identified. The majority were postmenopausal, estrogen receptor-positive, and had large (often neglected) primary lesions. Eleven patients were asymptomatic with respect to their skeletal metastases, although bone scans and bone roentgenograms revealed multiple areas of involvement in all patients. The median survival from the time of diagnosis was 33 months (range, 1-74 months); the 5-year actuarial survival was 45%. Systemic therapy with hormones or chemotherapy was effective in producing subjective responses; radiotherapy to painful bony areas was also an effective palliative treatment. Median survival in this group of patients was significantly improved when compared to our breast cancer patients who had extraskeletal metastases at initial diagnosis (33 versus 9 months, respectively), and to previously reported series of breast cancer patients with metastases at initial diagnosis. Since patients with Stage IV breast cancer and metastases limited to the skeleton often have prolonged survival, complications from bone metastases (e.g. pathologic fracture, epidural spinal cord compression) and other intercurrent illnesses should be managed aggressively.

Original languageEnglish (US)
Pages (from-to)178-182
Number of pages5
JournalCancer
Volume58
Issue number1
StatePublished - 1986

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Breast Neoplasms
Neoplasm Metastasis
Survival
Bone and Bones
Spontaneous Fractures
Spinal Cord Compression
Palliative Care
Skeleton
Estrogen Receptors
Breast
Radiotherapy
Hormones
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Breast cancer with skeletal metastases at initial diagnosis : Distinctive clinical characteristics and favorable prognosis. / Sherry, M. M.; Greco, F. A.; Johnson, D. H.; Hainsworth, J. D.

In: Cancer, Vol. 58, No. 1, 1986, p. 178-182.

Research output: Contribution to journalArticle

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