Breast carcinoma with chondroid differentiation: A clinicopathologic study of 21 triple negative (ER-, PR-, Her2/neu-) cases

Katja Gwin, Darren T. Wheeler, Veerle Bossuyt, Fattaneh A. Tavassoli

Research output: Contribution to journalArticle

18 Scopus citations


A total of 21 metaplastic breast carcinomas (MCs) with chondroid differentiation were evaluated to better establish the clinicopathological features of this variant. The tumors exhibited mainly invasive carcinoma admixed with areas of cartilaginous matrix production. An associated ductal intraepithelial neoplasia component grade 2 or 3 was observed in 43% of cases. Immunohistochemical analysis revealed a triple negative (ER-, PR-, and Her2/neu-) immunoprofile and no expression of the androgen receptor. EGFR-positivity was found in 88% of evaluated cases, consistent with the proposed basaloid phenotype for all MC. Compared with previous studies that reviewed MC with osseus and cartilaginous elements, the incidence of axillary lymph node metastasis was significantly higher in our study and 60% of positive nodes exhibited chondroid differentiation. Available follow-up data (n = 10) revealed aggressive behavior of this MC variant with frequent metastasis, including visceral involvement and local chest wall recurrence despite chemotherapy and radiation. Three patients subsequently died of metastatic disease.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalInternational Journal of Surgical Pathology
Issue number1
StatePublished - Feb 2010



  • Breast
  • Carcinoma
  • Chondroid differentiation
  • EGFR
  • Matrix producing carcinoma
  • Metaplastic

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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