Breast Conservation in the Setting of Contemporary Multimodality Treatment Provides Excellent Outcomes for Patients with Occult Primary Breast Cancer

Natasha M. Rueth, Dalliah M. Black, Angela R. Limmer, Emmanuel Gabriel, Lei Huo, Bruno D. Fornage, Basak E. Dogan, Mariana Chavez-MacGregor, Min Yi, Kelly K. Hunt, Eric A. Strom

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Conclusions: Breast conservation—performed with contemporary imaging and multimodality treatment—provides excellent local control and survival for women with T0N+ breast cancer and can be safely offered instead of mastectomy.

Purpose: To evaluate recurrence and survival for patients with occult (T0N+) breast cancer who underwent contemporary treatment, assessing outcomes for breast conservation and mastectomy.

Methods: We performed a single-institution review of women with occult breast cancer presenting with axillary metastasis without identifiable breast tumor or distant metastasis. We excluded patients with tumors in the axillary tail or mastectomy specimen, patients with additional nonbreast cancer diagnoses, and patients with a history of breast cancer. Breast conservation was defined as axillary node dissection with radiation therapy, without breast surgery. We evaluated patient, tumor, treatment, and outcome variables. Patients were assessed for local, regional, and distant recurrences. Overall survival was calculated using the Kaplan–Meier method.

Results: Thirty-six patients met criteria for occult breast cancer. Most of these patients (77.8 %) had N1 disease. Fifty percent of cancers (n = 18) were estrogen receptor–positive; 12 (33.3 %) were triple-negative. All patients were evaluated with mammography. Thirty-five patients had breast ultrasound (97.2 %) and 33 (91.7 %) had an MRI. Thirty-four patients (94.4 %) were treated with chemotherapy and 33 (91.7 %) with radiotherapy. Twenty-seven patients (75.0 %) were treated with breast conservation. The median follow-up was 64 months. There were no local or regional failures. One distant recurrence occurred >5 years after diagnosis, resulting in a 5-years overall survival rate of 100 %. There were no significant survival differences between patients receiving breast conservation versus mastectomy (p = 0.7).

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalAnnals of Surgical Oncology
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2015

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Breast
Breast Neoplasms
Mastectomy
Therapeutics
Survival
Recurrence
Neoplasms
Radiotherapy
Neoplasm Metastasis
Mammography
Dissection
Estrogens
Survival Rate
Drug Therapy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Breast Conservation in the Setting of Contemporary Multimodality Treatment Provides Excellent Outcomes for Patients with Occult Primary Breast Cancer. / Rueth, Natasha M.; Black, Dalliah M.; Limmer, Angela R.; Gabriel, Emmanuel; Huo, Lei; Fornage, Bruno D.; Dogan, Basak E.; Chavez-MacGregor, Mariana; Yi, Min; Hunt, Kelly K.; Strom, Eric A.

In: Annals of Surgical Oncology, Vol. 22, No. 1, 01.01.2015, p. 90-95.

Research output: Contribution to journalArticle

Rueth, NM, Black, DM, Limmer, AR, Gabriel, E, Huo, L, Fornage, BD, Dogan, BE, Chavez-MacGregor, M, Yi, M, Hunt, KK & Strom, EA 2015, 'Breast Conservation in the Setting of Contemporary Multimodality Treatment Provides Excellent Outcomes for Patients with Occult Primary Breast Cancer', Annals of Surgical Oncology, vol. 22, no. 1, pp. 90-95. https://doi.org/10.1245/s10434-014-3991-0
Rueth, Natasha M. ; Black, Dalliah M. ; Limmer, Angela R. ; Gabriel, Emmanuel ; Huo, Lei ; Fornage, Bruno D. ; Dogan, Basak E. ; Chavez-MacGregor, Mariana ; Yi, Min ; Hunt, Kelly K. ; Strom, Eric A. / Breast Conservation in the Setting of Contemporary Multimodality Treatment Provides Excellent Outcomes for Patients with Occult Primary Breast Cancer. In: Annals of Surgical Oncology. 2015 ; Vol. 22, No. 1. pp. 90-95.
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abstract = "Conclusions: Breast conservation—performed with contemporary imaging and multimodality treatment—provides excellent local control and survival for women with T0N+ breast cancer and can be safely offered instead of mastectomy.Purpose: To evaluate recurrence and survival for patients with occult (T0N+) breast cancer who underwent contemporary treatment, assessing outcomes for breast conservation and mastectomy.Methods: We performed a single-institution review of women with occult breast cancer presenting with axillary metastasis without identifiable breast tumor or distant metastasis. We excluded patients with tumors in the axillary tail or mastectomy specimen, patients with additional nonbreast cancer diagnoses, and patients with a history of breast cancer. Breast conservation was defined as axillary node dissection with radiation therapy, without breast surgery. We evaluated patient, tumor, treatment, and outcome variables. Patients were assessed for local, regional, and distant recurrences. Overall survival was calculated using the Kaplan–Meier method.Results: Thirty-six patients met criteria for occult breast cancer. Most of these patients (77.8 {\%}) had N1 disease. Fifty percent of cancers (n = 18) were estrogen receptor–positive; 12 (33.3 {\%}) were triple-negative. All patients were evaluated with mammography. Thirty-five patients had breast ultrasound (97.2 {\%}) and 33 (91.7 {\%}) had an MRI. Thirty-four patients (94.4 {\%}) were treated with chemotherapy and 33 (91.7 {\%}) with radiotherapy. Twenty-seven patients (75.0 {\%}) were treated with breast conservation. The median follow-up was 64 months. There were no local or regional failures. One distant recurrence occurred >5 years after diagnosis, resulting in a 5-years overall survival rate of 100 {\%}. There were no significant survival differences between patients receiving breast conservation versus mastectomy (p = 0.7).",
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AU - Rueth, Natasha M.

AU - Black, Dalliah M.

AU - Limmer, Angela R.

AU - Gabriel, Emmanuel

AU - Huo, Lei

AU - Fornage, Bruno D.

AU - Dogan, Basak E.

AU - Chavez-MacGregor, Mariana

AU - Yi, Min

AU - Hunt, Kelly K.

AU - Strom, Eric A.

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N2 - Conclusions: Breast conservation—performed with contemporary imaging and multimodality treatment—provides excellent local control and survival for women with T0N+ breast cancer and can be safely offered instead of mastectomy.Purpose: To evaluate recurrence and survival for patients with occult (T0N+) breast cancer who underwent contemporary treatment, assessing outcomes for breast conservation and mastectomy.Methods: We performed a single-institution review of women with occult breast cancer presenting with axillary metastasis without identifiable breast tumor or distant metastasis. We excluded patients with tumors in the axillary tail or mastectomy specimen, patients with additional nonbreast cancer diagnoses, and patients with a history of breast cancer. Breast conservation was defined as axillary node dissection with radiation therapy, without breast surgery. We evaluated patient, tumor, treatment, and outcome variables. Patients were assessed for local, regional, and distant recurrences. Overall survival was calculated using the Kaplan–Meier method.Results: Thirty-six patients met criteria for occult breast cancer. Most of these patients (77.8 %) had N1 disease. Fifty percent of cancers (n = 18) were estrogen receptor–positive; 12 (33.3 %) were triple-negative. All patients were evaluated with mammography. Thirty-five patients had breast ultrasound (97.2 %) and 33 (91.7 %) had an MRI. Thirty-four patients (94.4 %) were treated with chemotherapy and 33 (91.7 %) with radiotherapy. Twenty-seven patients (75.0 %) were treated with breast conservation. The median follow-up was 64 months. There were no local or regional failures. One distant recurrence occurred >5 years after diagnosis, resulting in a 5-years overall survival rate of 100 %. There were no significant survival differences between patients receiving breast conservation versus mastectomy (p = 0.7).

AB - Conclusions: Breast conservation—performed with contemporary imaging and multimodality treatment—provides excellent local control and survival for women with T0N+ breast cancer and can be safely offered instead of mastectomy.Purpose: To evaluate recurrence and survival for patients with occult (T0N+) breast cancer who underwent contemporary treatment, assessing outcomes for breast conservation and mastectomy.Methods: We performed a single-institution review of women with occult breast cancer presenting with axillary metastasis without identifiable breast tumor or distant metastasis. We excluded patients with tumors in the axillary tail or mastectomy specimen, patients with additional nonbreast cancer diagnoses, and patients with a history of breast cancer. Breast conservation was defined as axillary node dissection with radiation therapy, without breast surgery. We evaluated patient, tumor, treatment, and outcome variables. Patients were assessed for local, regional, and distant recurrences. Overall survival was calculated using the Kaplan–Meier method.Results: Thirty-six patients met criteria for occult breast cancer. Most of these patients (77.8 %) had N1 disease. Fifty percent of cancers (n = 18) were estrogen receptor–positive; 12 (33.3 %) were triple-negative. All patients were evaluated with mammography. Thirty-five patients had breast ultrasound (97.2 %) and 33 (91.7 %) had an MRI. Thirty-four patients (94.4 %) were treated with chemotherapy and 33 (91.7 %) with radiotherapy. Twenty-seven patients (75.0 %) were treated with breast conservation. The median follow-up was 64 months. There were no local or regional failures. One distant recurrence occurred >5 years after diagnosis, resulting in a 5-years overall survival rate of 100 %. There were no significant survival differences between patients receiving breast conservation versus mastectomy (p = 0.7).

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