Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters

Yueqing Gu; Vincent Bourke; Jae G. Kim; Mengna Xia; Anca Constantinescu; Ralph P. Mason; Hanli Liu

doi:10.1117/12.479465

Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters

Yueqing Gu, Vincent Bourke, Jae G. Kim, Mengna Xia, Anca Constantinescu, Ralph P. Mason, Hanli Liu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO ₂, tumor vascular oxygenated hemoglobin concentration [HbO ₂], and tumor oxygen tension pO ₂) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY™) to evaluate dynamic responses of breast tumors to carbogen (5% CO ₂ and 95% O ₂) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO ₂, followed by changes in global tumor vascular [HbO ₂], and delayed responses for pO ₂. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	B. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca
Pages	416-423
Number of pages	8
Volume	4955
DOIs	https://doi.org/10.1117/12.479465
State	Published - 2003
Event	PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V - San Jose, CA, United States Duration: Jan 26 2003 → Jan 29 2003

Other

Other	PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V
Country/Territory	United States
City	San Jose, CA
Period	1/26/03 → 1/29/03

Keywords

Breast tumor
Carbogen intervention
Fluorescence quenching
NIRS
Tumor oxygenation

ASJC Scopus subject areas

Electrical and Electronic Engineering
Condensed Matter Physics

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10.1117/12.479465

Cite this

Gu, Y., Bourke, V., Kim, J. G., Xia, M., Constantinescu, A., Mason, R. P., & Liu, H. (2003). Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters. In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraca (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4955, pp. 416-423) https://doi.org/10.1117/12.479465

Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters. / Gu, Yueqing; Bourke, Vincent; Kim, Jae G. et al.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / B. Chance; R.R. Alfano; B.J. Tromberg; M. Tamura; E.M. Sevick-Muraca. Vol. 4955 2003. p. 416-423.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gu, Y, Bourke, V, Kim, JG, Xia, M, Constantinescu, A, Mason, RP & Liu, H 2003, Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters. in B Chance, RR Alfano, BJ Tromberg, M Tamura & EM Sevick-Muraca (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4955, pp. 416-423, PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V, San Jose, CA, United States, 1/26/03. https://doi.org/10.1117/12.479465

Gu Y, Bourke V, Kim JG, Xia M, Constantinescu A, Mason RP et al. Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters. In Chance B, Alfano RR, Tromberg BJ, Tamura M, Sevick-Muraca EM, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4955. 2003. p. 416-423 doi: 10.1117/12.479465

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title = "Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters",

abstract = "Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO 2, tumor vascular oxygenated hemoglobin concentration [HbO 2], and tumor oxygen tension pO 2) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY{\texttrademark}) to evaluate dynamic responses of breast tumors to carbogen (5% CO 2 and 95% O 2) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO 2, followed by changes in global tumor vascular [HbO 2], and delayed responses for pO 2. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time. ",

keywords = "Breast tumor, Carbogen intervention, Fluorescence quenching, NIRS, Tumor oxygenation",

author = "Yueqing Gu and Vincent Bourke and Kim, {Jae G.} and Mengna Xia and Anca Constantinescu and Mason, {Ralph P.} and Hanli Liu",

year = "2003",

doi = "10.1117/12.479465",

language = "English (US)",

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pages = "416--423",

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AU - Gu, Yueqing

AU - Bourke, Vincent

AU - Kim, Jae G.

AU - Xia, Mengna

AU - Constantinescu, Anca

AU - Mason, Ralph P.

AU - Liu, Hanli

PY - 2003

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N2 - Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO 2, tumor vascular oxygenated hemoglobin concentration [HbO 2], and tumor oxygen tension pO 2) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY™) to evaluate dynamic responses of breast tumors to carbogen (5% CO 2 and 95% O 2) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO 2, followed by changes in global tumor vascular [HbO 2], and delayed responses for pO 2. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time.

AB - Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO 2, tumor vascular oxygenated hemoglobin concentration [HbO 2], and tumor oxygen tension pO 2) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY™) to evaluate dynamic responses of breast tumors to carbogen (5% CO 2 and 95% O 2) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO 2, followed by changes in global tumor vascular [HbO 2], and delayed responses for pO 2. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time.

KW - Breast tumor

KW - Carbogen intervention

KW - Fluorescence quenching

KW - NIRS

KW - Tumor oxygenation

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ER -

Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters

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