Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters

Yueqing Gu, Vincent Bourke, Jae G. Kim, Mengna Xia, Anca Constantinescu, Ralph P. Mason, Hanli Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO 2, tumor vascular oxygenated hemoglobin concentration [HbO 2], and tumor oxygen tension pO 2) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY™) to evaluate dynamic responses of breast tumors to carbogen (5% CO 2 and 95% O 2) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO 2, followed by changes in global tumor vascular [HbO 2], and delayed responses for pO 2. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsB. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca
Pages416-423
Number of pages8
Volume4955
DOIs
StatePublished - 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V - San Jose, CA, United States
Duration: Jan 26 2003Jan 29 2003

Other

OtherPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V
CountryUnited States
CitySan Jose, CA
Period1/26/031/29/03

Keywords

  • Breast tumor
  • Carbogen intervention
  • Fluorescence quenching
  • NIRS
  • Tumor oxygenation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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  • Cite this

    Gu, Y., Bourke, V., Kim, J. G., Xia, M., Constantinescu, A., Mason, R. P., & Liu, H. (2003). Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters. In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraca (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4955, pp. 416-423) https://doi.org/10.1117/12.479465