Breathing new life into the rational design of Alzheimer's therapeutics

Daniel R. Dries, Gang Yu

Research output: Contribution to journalArticlepeer-review

Abstract

γ-secretase is a promising therapeutic target for Alzheimer's disease, but all inhibitors and modulators have failed due to toxicity or low efficacy. In this issue of Cell, Yang et al. provide cryo-EM structures of γ-secretase individually bound to three inhibitors and a modulator, giving new promise to targeting γ-secretase therapeutically.

Original languageEnglish (US)
Pages (from-to)296-298
Number of pages3
JournalCell
Volume184
Issue number2
DOIs
StatePublished - Jan 21 2021

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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