TY - JOUR
T1 - Brick by brick
T2 - metabolism and tumor cell growth
AU - DeBerardinis, Ralph J.
AU - Sayed, Nabil
AU - Ditsworth, Dara
AU - Thompson, Craig B.
N1 - Funding Information:
The authors thank members of the Thompson laboratory for critical reading of the manuscript. This work is supported by National Institutes of Health grants PO1 CA104838 (CBT) and K08 DK072565 (RJD).
PY - 2008/2
Y1 - 2008/2
N2 - Tumor cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. Classical work in tumor cell metabolism focused on bioenergetics, particularly enhanced glycolysis and suppressed oxidative phosphorylation (the 'Warburg effect'). But the biosynthetic activities required to create daughter cells are equally important for tumor growth, and recent studies are now bringing these pathways into focus. In this review, we discuss how tumor cells achieve high rates of nucleotide and fatty acid synthesis, how oncogenes and tumor suppressors influence these activities, and how glutamine metabolism enables macromolecular synthesis in proliferating cells.
AB - Tumor cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. Classical work in tumor cell metabolism focused on bioenergetics, particularly enhanced glycolysis and suppressed oxidative phosphorylation (the 'Warburg effect'). But the biosynthetic activities required to create daughter cells are equally important for tumor growth, and recent studies are now bringing these pathways into focus. In this review, we discuss how tumor cells achieve high rates of nucleotide and fatty acid synthesis, how oncogenes and tumor suppressors influence these activities, and how glutamine metabolism enables macromolecular synthesis in proliferating cells.
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U2 - 10.1016/j.gde.2008.02.003
DO - 10.1016/j.gde.2008.02.003
M3 - Review article
C2 - 18387799
AN - SCOPUS:43749083041
SN - 0959-437X
VL - 18
SP - 54
EP - 61
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 1
ER -