Broad spectrum identification of SUMO substrates in melanoma cells

Anand K. Ganesan, Yoonjung Kho, Chan Kim Sung, Yue Chen, Yingming Zhao, Michael A. White

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Like phosphorylation, protein sumoylation likely represents a dynamic PTM to alter protein function in support of cell regulatory systems. The broad-spectrum impact of transient or chronic engagement of signal transduction cascades on protein sumoylation has not been explored. Here, we find that epidermal growth factor (EGF) stimulation evokes a rapid alteration in small ubiquitin modifier (SUMO) target selection, while oncogene expression alters steady-state SUMO-protein profiles. A proteomic SUMO target analysis in melanoma cells identified proteins involved in cellular signaling, growth control, and neural differentiation.

Original languageEnglish (US)
Pages (from-to)2216-2221
Number of pages6
JournalProteomics
Volume7
Issue number13
DOIs
StatePublished - Jun 1 2007

Keywords

  • BRAF
  • Melanoma
  • SUMO
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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    Ganesan, A. K., Kho, Y., Sung, C. K., Chen, Y., Zhao, Y., & White, M. A. (2007). Broad spectrum identification of SUMO substrates in melanoma cells. Proteomics, 7(13), 2216-2221. https://doi.org/10.1002/pmic.200600971