Bronchial airway anastomotic complications after pediatric lung transplantation: Incidence, cause, management, and outcome

Cliff K. Choong, Stuart C. Sweet, Jennifer Bell Zoole, Tracey J. Guthrie, Eric N. Mendeloff, Fabio J. Haddad, Pam Schuler, Maite De La Morena, Charles B. Huddleston

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Objective: Airway complications are a recognized surgical complication and an important source of morbidity after adult lung transplantation. Little is known about these complications after pediatric lung transplantation. Methods: Data of pediatric lung transplants performed between January 1990 and December 2002 in a single pediatric institution were reviewed retrospectively. Results: A total of 214 patients, with a mean age of 9.8 ± 6.1 years (range 0.01-19.7 years), underwent 239 lung transplants: 231 bilateral and 8 single. Mean follow-up was 3.4 years. Forty-two airway complications requiring interventions (stenosis = 36; dehiscence = 4; malacia = 2) developed in 30 recipients (complication rate: 9% of 470 bronchial anastomoses at risk). There were airway complications in 29 bilateral lung transplants (13%) and 1 single lung transplant (13%). Mean time to diagnosis was 51 ± 27 days (median: 53, range 1-96 days), and diagnoses were made in 90% of patients within the first 3 months after transplantation. Preoperative Pseudomonas cepacia, postoperative fungal lung infection, and days on mechanical ventilator were found to be significant risk factors on multivariate analysis (P = .002, P = .013 and P = .003, respectively). Treatment included rigid bronchoscopic dilatation in 17 patients, balloon dilatation in 13 patients, and stent placement in 12 patients. Other treatments consisted of debridement, fibrin glue application, chest tube placement, and pneumonectomy followed by retransplantation. No patients died as a direct result of airway complications. There was no significant difference in the incidence of bronchiolitis obliterans or overall survival in comparison with patients who did not have airway complications. Conclusions: Airway complications are a significant cause of morbidity after pediatric lung transplantation. The majority are successfully treated, and patient outcomes are not adversely affected.

Original languageEnglish (US)
Pages (from-to)198-203
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume131
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Lung Transplantation
Pediatrics
Incidence
Lung
Transplants
Dilatation
Bronchiolitis Obliterans
Morbidity
Burkholderia cepacia
Chest Tubes
Fibrin Tissue Adhesive
Pneumonectomy
Mycoses
Debridement
Mechanical Ventilators
Stents
Pathologic Constriction
Multivariate Analysis
Transplantation
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Choong, C. K., Sweet, S. C., Zoole, J. B., Guthrie, T. J., Mendeloff, E. N., Haddad, F. J., ... Huddleston, C. B. (2006). Bronchial airway anastomotic complications after pediatric lung transplantation: Incidence, cause, management, and outcome. Journal of Thoracic and Cardiovascular Surgery, 131(1), 198-203. https://doi.org/10.1016/j.jtcvs.2005.06.053

Bronchial airway anastomotic complications after pediatric lung transplantation : Incidence, cause, management, and outcome. / Choong, Cliff K.; Sweet, Stuart C.; Zoole, Jennifer Bell; Guthrie, Tracey J.; Mendeloff, Eric N.; Haddad, Fabio J.; Schuler, Pam; De La Morena, Maite; Huddleston, Charles B.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 131, No. 1, 01.2006, p. 198-203.

Research output: Contribution to journalArticle

Choong, CK, Sweet, SC, Zoole, JB, Guthrie, TJ, Mendeloff, EN, Haddad, FJ, Schuler, P, De La Morena, M & Huddleston, CB 2006, 'Bronchial airway anastomotic complications after pediatric lung transplantation: Incidence, cause, management, and outcome', Journal of Thoracic and Cardiovascular Surgery, vol. 131, no. 1, pp. 198-203. https://doi.org/10.1016/j.jtcvs.2005.06.053
Choong, Cliff K. ; Sweet, Stuart C. ; Zoole, Jennifer Bell ; Guthrie, Tracey J. ; Mendeloff, Eric N. ; Haddad, Fabio J. ; Schuler, Pam ; De La Morena, Maite ; Huddleston, Charles B. / Bronchial airway anastomotic complications after pediatric lung transplantation : Incidence, cause, management, and outcome. In: Journal of Thoracic and Cardiovascular Surgery. 2006 ; Vol. 131, No. 1. pp. 198-203.
@article{3744c70e5c014285a4b4e5474dad8098,
title = "Bronchial airway anastomotic complications after pediatric lung transplantation: Incidence, cause, management, and outcome",
abstract = "Objective: Airway complications are a recognized surgical complication and an important source of morbidity after adult lung transplantation. Little is known about these complications after pediatric lung transplantation. Methods: Data of pediatric lung transplants performed between January 1990 and December 2002 in a single pediatric institution were reviewed retrospectively. Results: A total of 214 patients, with a mean age of 9.8 ± 6.1 years (range 0.01-19.7 years), underwent 239 lung transplants: 231 bilateral and 8 single. Mean follow-up was 3.4 years. Forty-two airway complications requiring interventions (stenosis = 36; dehiscence = 4; malacia = 2) developed in 30 recipients (complication rate: 9{\%} of 470 bronchial anastomoses at risk). There were airway complications in 29 bilateral lung transplants (13{\%}) and 1 single lung transplant (13{\%}). Mean time to diagnosis was 51 ± 27 days (median: 53, range 1-96 days), and diagnoses were made in 90{\%} of patients within the first 3 months after transplantation. Preoperative Pseudomonas cepacia, postoperative fungal lung infection, and days on mechanical ventilator were found to be significant risk factors on multivariate analysis (P = .002, P = .013 and P = .003, respectively). Treatment included rigid bronchoscopic dilatation in 17 patients, balloon dilatation in 13 patients, and stent placement in 12 patients. Other treatments consisted of debridement, fibrin glue application, chest tube placement, and pneumonectomy followed by retransplantation. No patients died as a direct result of airway complications. There was no significant difference in the incidence of bronchiolitis obliterans or overall survival in comparison with patients who did not have airway complications. Conclusions: Airway complications are a significant cause of morbidity after pediatric lung transplantation. The majority are successfully treated, and patient outcomes are not adversely affected.",
author = "Choong, {Cliff K.} and Sweet, {Stuart C.} and Zoole, {Jennifer Bell} and Guthrie, {Tracey J.} and Mendeloff, {Eric N.} and Haddad, {Fabio J.} and Pam Schuler and {De La Morena}, Maite and Huddleston, {Charles B.}",
year = "2006",
month = "1",
doi = "10.1016/j.jtcvs.2005.06.053",
language = "English (US)",
volume = "131",
pages = "198--203",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Bronchial airway anastomotic complications after pediatric lung transplantation

T2 - Incidence, cause, management, and outcome

AU - Choong, Cliff K.

AU - Sweet, Stuart C.

AU - Zoole, Jennifer Bell

AU - Guthrie, Tracey J.

AU - Mendeloff, Eric N.

AU - Haddad, Fabio J.

AU - Schuler, Pam

AU - De La Morena, Maite

AU - Huddleston, Charles B.

PY - 2006/1

Y1 - 2006/1

N2 - Objective: Airway complications are a recognized surgical complication and an important source of morbidity after adult lung transplantation. Little is known about these complications after pediatric lung transplantation. Methods: Data of pediatric lung transplants performed between January 1990 and December 2002 in a single pediatric institution were reviewed retrospectively. Results: A total of 214 patients, with a mean age of 9.8 ± 6.1 years (range 0.01-19.7 years), underwent 239 lung transplants: 231 bilateral and 8 single. Mean follow-up was 3.4 years. Forty-two airway complications requiring interventions (stenosis = 36; dehiscence = 4; malacia = 2) developed in 30 recipients (complication rate: 9% of 470 bronchial anastomoses at risk). There were airway complications in 29 bilateral lung transplants (13%) and 1 single lung transplant (13%). Mean time to diagnosis was 51 ± 27 days (median: 53, range 1-96 days), and diagnoses were made in 90% of patients within the first 3 months after transplantation. Preoperative Pseudomonas cepacia, postoperative fungal lung infection, and days on mechanical ventilator were found to be significant risk factors on multivariate analysis (P = .002, P = .013 and P = .003, respectively). Treatment included rigid bronchoscopic dilatation in 17 patients, balloon dilatation in 13 patients, and stent placement in 12 patients. Other treatments consisted of debridement, fibrin glue application, chest tube placement, and pneumonectomy followed by retransplantation. No patients died as a direct result of airway complications. There was no significant difference in the incidence of bronchiolitis obliterans or overall survival in comparison with patients who did not have airway complications. Conclusions: Airway complications are a significant cause of morbidity after pediatric lung transplantation. The majority are successfully treated, and patient outcomes are not adversely affected.

AB - Objective: Airway complications are a recognized surgical complication and an important source of morbidity after adult lung transplantation. Little is known about these complications after pediatric lung transplantation. Methods: Data of pediatric lung transplants performed between January 1990 and December 2002 in a single pediatric institution were reviewed retrospectively. Results: A total of 214 patients, with a mean age of 9.8 ± 6.1 years (range 0.01-19.7 years), underwent 239 lung transplants: 231 bilateral and 8 single. Mean follow-up was 3.4 years. Forty-two airway complications requiring interventions (stenosis = 36; dehiscence = 4; malacia = 2) developed in 30 recipients (complication rate: 9% of 470 bronchial anastomoses at risk). There were airway complications in 29 bilateral lung transplants (13%) and 1 single lung transplant (13%). Mean time to diagnosis was 51 ± 27 days (median: 53, range 1-96 days), and diagnoses were made in 90% of patients within the first 3 months after transplantation. Preoperative Pseudomonas cepacia, postoperative fungal lung infection, and days on mechanical ventilator were found to be significant risk factors on multivariate analysis (P = .002, P = .013 and P = .003, respectively). Treatment included rigid bronchoscopic dilatation in 17 patients, balloon dilatation in 13 patients, and stent placement in 12 patients. Other treatments consisted of debridement, fibrin glue application, chest tube placement, and pneumonectomy followed by retransplantation. No patients died as a direct result of airway complications. There was no significant difference in the incidence of bronchiolitis obliterans or overall survival in comparison with patients who did not have airway complications. Conclusions: Airway complications are a significant cause of morbidity after pediatric lung transplantation. The majority are successfully treated, and patient outcomes are not adversely affected.

UR - http://www.scopus.com/inward/record.url?scp=30044445013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30044445013&partnerID=8YFLogxK

U2 - 10.1016/j.jtcvs.2005.06.053

DO - 10.1016/j.jtcvs.2005.06.053

M3 - Article

C2 - 16399312

AN - SCOPUS:30044445013

VL - 131

SP - 198

EP - 203

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

IS - 1

ER -