Brucella abortus DNA is a major bacterial agonist to activate the host innate immune system

Priscila Carneiro Campos, Marco Túlio Ribeiro Gomes, Gabriela Guimarães, Miriam Maria Silva Costa Franco, Fernanda Martins Marim, Sergio Costa Oliveira

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Immunity against Brucella abortus depends on the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). Signaling pathways triggered by Brucella DNA involves TLR9, AIM2 and possibly STING and MAVS. Herein, we review the advances in B. abortus DNA sensing by host innate immune receptors and the progress in this field.

Original languageEnglish (US)
Pages (from-to)979-984
Number of pages6
JournalMicrobes and Infection
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • Bacterial DNA
  • Brucella abortus
  • Cytosolic sensors
  • Innate immunity
  • TLRs

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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