Bryostatins

The asymmetric synthesis of the C1-C9 and C17-C27 fragments

J. De Brabander, M. Vandewalle

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The construction of the fragments C1-C9 3 and C17-C27 4a of the bryostatins in an enantioselective and highly diastereoselective fashion is described. The usefulness of the 'chiron' approach is illustrated with the synthesis of these fragments from, respectively, D-pantolactone (6) and D-isobutyl lactate (23) as chiral templates.

Original languageEnglish (US)
Pages (from-to)855-865
Number of pages11
JournalSynthesis
Issue number8
StatePublished - 1994

Fingerprint

Bryostatins
pantolactone
isobutyl lactate
chiron

Keywords

  • aldol and reduction reactions
  • D-isobutyl lactate
  • D-pantolactone
  • diastereoselectivity in alkylation
  • marine natural products

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Bryostatins : The asymmetric synthesis of the C1-C9 and C17-C27 fragments. / De Brabander, J.; Vandewalle, M.

In: Synthesis, No. 8, 1994, p. 855-865.

Research output: Contribution to journalArticle

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