Burn injury enhances alveolar macrophage endotoxin sensitivity

J. G. Williams, P. Bankey, J. P. Minei, K. McIntyre, T. Turbeville

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Systemic activation of inflammatory cascades has been implicated in the pathogenesis of the multiple organ dysfunction syndrome. To begin to determine whether dysregulation of macrophage cytokine expression after burn plays a role in organ failure, we examined tumor necrosis factor α bioactivity of liver and lung macrophages under two conditions: (1) at 1, 3, 5, and 7 days after 40% scald burn, and (2) after sequential insult consisting of 40% scald burn followed by in vitro incubation with endotoxin. Burn alone did not significantly alter alveolar macrophage or Kupffer cell tumor necrosis factor α bioactivity at any of the timepoints examined. Sequential insult did not result in significant changes in Kupffer cell tumor necrosis factor α, but tumor necrosis factor α was increased 11.1 times in alveolar macrophages harvested on postburn day 3. Therefore macrophage cytokine responses to thermal injury are apparently both tissue-specific and time-dependent.

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalJournal of Burn Care and Rehabilitation
Volume15
Issue number6
DOIs
StatePublished - 1994

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Alveolar Macrophages
Endotoxins
Tumor Necrosis Factor-alpha
Kupffer Cells
Macrophages
Wounds and Injuries
Cytokines
Alveolar Epithelial Cells
Multiple Organ Failure
Hot Temperature
Lung
Liver

ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine

Cite this

Burn injury enhances alveolar macrophage endotoxin sensitivity. / Williams, J. G.; Bankey, P.; Minei, J. P.; McIntyre, K.; Turbeville, T.

In: Journal of Burn Care and Rehabilitation, Vol. 15, No. 6, 1994, p. 493-498.

Research output: Contribution to journalArticle

Williams, J. G. ; Bankey, P. ; Minei, J. P. ; McIntyre, K. ; Turbeville, T. / Burn injury enhances alveolar macrophage endotoxin sensitivity. In: Journal of Burn Care and Rehabilitation. 1994 ; Vol. 15, No. 6. pp. 493-498.
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