Buspirone, a non-benzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity

Manjit K. Sanghera, Brian A. Mcmillen, Dwight C. German

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

It has been hypothesized that treatments which increase locus coeruleus (LC) noradrenergic neuronal activity produce anxiety, whereas treatments which decrease LC neuronal activity are anxiety-reducing. Although the benzodiazepine anxiolytic diazepam decreases LC neuronal impulse flow and norepinephrine metabolism, the non-benzodiazepine anxiolytic buspirone does the opposite. These data suggest that a reduction in LC output is not a necessary prerequisite for anxiolytic activity.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalEuropean Journal of Pharmacology
Volume86
Issue number1
DOIs
StatePublished - Dec 17 1982

Keywords

  • Anxiety
  • Buspirone
  • Diazepam
  • Locus coeruleus
  • Norepinephrine

ASJC Scopus subject areas

  • Pharmacology

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