Buspirone, a non-benzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity

Manjit K. Sanghera, Brian A. Mcmillen, Dwight C. German

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

It has been hypothesized that treatments which increase locus coeruleus (LC) noradrenergic neuronal activity produce anxiety, whereas treatments which decrease LC neuronal activity are anxiety-reducing. Although the benzodiazepine anxiolytic diazepam decreases LC neuronal impulse flow and norepinephrine metabolism, the non-benzodiazepine anxiolytic buspirone does the opposite. These data suggest that a reduction in LC output is not a necessary prerequisite for anxiolytic activity.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalEuropean Journal of Pharmacology
Volume86
Issue number1
DOIs
StatePublished - Dec 17 1982

Fingerprint

Buspirone
Locus Coeruleus
Anti-Anxiety Agents
Anxiety
Diazepam
Benzodiazepines
Norepinephrine

Keywords

  • Anxiety
  • Buspirone
  • Diazepam
  • Locus coeruleus
  • Norepinephrine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Buspirone, a non-benzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity. / Sanghera, Manjit K.; Mcmillen, Brian A.; German, Dwight C.

In: European Journal of Pharmacology, Vol. 86, No. 1, 17.12.1982, p. 107-110.

Research output: Contribution to journalArticle

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