Buspirone, a non-benzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity

Manjit K. Sanghera, Brian A. Mcmillen, Dwight C. German

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

It has been hypothesized that treatments which increase locus coeruleus (LC) noradrenergic neuronal activity produce anxiety, whereas treatments which decrease LC neuronal activity are anxiety-reducing. Although the benzodiazepine anxiolytic diazepam decreases LC neuronal impulse flow and norepinephrine metabolism, the non-benzodiazepine anxiolytic buspirone does the opposite. These data suggest that a reduction in LC output is not a necessary prerequisite for anxiolytic activity.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalEuropean Journal of Pharmacology
Volume86
Issue number1
DOIs
StatePublished - Dec 17 1982

Keywords

  • Anxiety
  • Buspirone
  • Diazepam
  • Locus coeruleus
  • Norepinephrine

ASJC Scopus subject areas

  • Pharmacology

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