FRAGMENTS DE CLIVAGE DU C3 ET LA JONCTION DERMO-EPIDERMIQUE DE LA PEAU HUMAINE NORMALE

Translated title of the contribution: C3 cleavage fragments and the dermo-epidermal junction of normal human skin

N. Basset-Seguin, K. B. Yancey

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Recently, we have demonstrated the presence of C3dg deposits, a cleavage fragment of the third component of complement, on the basement membrane zone (MB) of normal human skin. These C3dg deposits are specific, isolated and not restricted to stratified squamous epithelia. Their origin is not thought to be due to passive incorporation of circulating C3dg within selected MB. Conversely, human keratinocytes are able to synthesize and secrete C3 and could represent a local source for these C3dg deposits. In situ production of C3 by epidermal cells could play a role in local inflammatory reactions. Similarly, a C3dg binding site(s) in selected basement membrane may account for the accumulation of C3-containing immune complexes in such tissues in pathological conditions.

Translated title of the contributionC3 cleavage fragments and the dermo-epidermal junction of normal human skin
Original languageFrench
Pages (from-to)629-634
Number of pages6
JournalAnnales de Dermatologie et de Venereologie
Volume119
Issue number9
StatePublished - Jan 1 1992

Keywords

  • C3
  • C3dg
  • basal membrane zone
  • human skin
  • keratinocytes

ASJC Scopus subject areas

  • Dermatology

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