Abstract
Recently, we have demonstrated the presence of C3dg deposits, a cleavage fragment of the third component of complement, on the basement membrane zone (MB) of normal human skin. These C3dg deposits are specific, isolated and not restricted to stratified squamous epithelia. Their origin is not thought to be due to passive incorporation of circulating C3dg within selected MB. Conversely, human keratinocytes are able to synthesize and secrete C3 and could represent a local source for these C3dg deposits. In situ production of C3 by epidermal cells could play a role in local inflammatory reactions. Similarly, a C3dg binding site(s) in selected basement membrane may account for the accumulation of C3-containing immune complexes in such tissues in pathological conditions.
| Original language | French |
|---|---|
| Pages (from-to) | 629-634 |
| Number of pages | 6 |
| Journal | Annales de Dermatologie et de Venereologie |
| Volume | 119 |
| Issue number | 9 |
| State | Published - 1992 |
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Keywords
- basal membrane zone
- C3
- C3dg
- human skin
- keratinocytes
ASJC Scopus subject areas
- Dermatology
Cite this
FRAGMENTS DE CLIVAGE DU C3 ET LA JONCTION DERMO-EPIDERMIQUE DE LA PEAU HUMAINE NORMALE. / Basset-Seguin, N.; Yancey, K. B.
In: Annales de Dermatologie et de Venereologie, Vol. 119, No. 9, 1992, p. 629-634.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - FRAGMENTS DE CLIVAGE DU C3 ET LA JONCTION DERMO-EPIDERMIQUE DE LA PEAU HUMAINE NORMALE
AU - Basset-Seguin, N.
AU - Yancey, K. B.
PY - 1992
Y1 - 1992
N2 - Recently, we have demonstrated the presence of C3dg deposits, a cleavage fragment of the third component of complement, on the basement membrane zone (MB) of normal human skin. These C3dg deposits are specific, isolated and not restricted to stratified squamous epithelia. Their origin is not thought to be due to passive incorporation of circulating C3dg within selected MB. Conversely, human keratinocytes are able to synthesize and secrete C3 and could represent a local source for these C3dg deposits. In situ production of C3 by epidermal cells could play a role in local inflammatory reactions. Similarly, a C3dg binding site(s) in selected basement membrane may account for the accumulation of C3-containing immune complexes in such tissues in pathological conditions.
AB - Recently, we have demonstrated the presence of C3dg deposits, a cleavage fragment of the third component of complement, on the basement membrane zone (MB) of normal human skin. These C3dg deposits are specific, isolated and not restricted to stratified squamous epithelia. Their origin is not thought to be due to passive incorporation of circulating C3dg within selected MB. Conversely, human keratinocytes are able to synthesize and secrete C3 and could represent a local source for these C3dg deposits. In situ production of C3 by epidermal cells could play a role in local inflammatory reactions. Similarly, a C3dg binding site(s) in selected basement membrane may account for the accumulation of C3-containing immune complexes in such tissues in pathological conditions.
KW - basal membrane zone
KW - C3
KW - C3dg
KW - human skin
KW - keratinocytes
UR - http://www.scopus.com/inward/record.url?scp=0026443027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026443027&partnerID=8YFLogxK
M3 - Article
VL - 119
SP - 629
EP - 634
JO - Annales de Dermatologie et de Venereologie
JF - Annales de Dermatologie et de Venereologie
SN - 0151-9638
IS - 9
ER -