C5a as a mediator of cutaneous inflammation

K. B. Yancey, R. A. Swerlick, T. J. Lawley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

C5a is an 11,000-dalton fragment of the fifth component of complement with potent anaphylatoxic and leukocyte chemotactic activities. Because C5a may play an important role in selected skin disorders as well as in systemic diseases with cutaneous manifestations, we have studied the clinical and histologic alterations produced by the intradermal injection of this potent soluble mediator of inflammatin in human skin in vivo. These studies have outlined the biologic properties of human C5a within the context of cells resident in the skin, the cutaneous microvasculature, and interacting cellular elements of peripheral blood.

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalAmerican Journal of Dermatopathology
Volume9
Issue number2
StatePublished - 1987

Fingerprint

Inflammation Mediators
Skin
Skin Manifestations
Intradermal Injections
Microvessels
Leukocytes

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Yancey, K. B., Swerlick, R. A., & Lawley, T. J. (1987). C5a as a mediator of cutaneous inflammation. American Journal of Dermatopathology, 9(2), 138-143.

C5a as a mediator of cutaneous inflammation. / Yancey, K. B.; Swerlick, R. A.; Lawley, T. J.

In: American Journal of Dermatopathology, Vol. 9, No. 2, 1987, p. 138-143.

Research output: Contribution to journalArticle

Yancey, KB, Swerlick, RA & Lawley, TJ 1987, 'C5a as a mediator of cutaneous inflammation', American Journal of Dermatopathology, vol. 9, no. 2, pp. 138-143.
Yancey, K. B. ; Swerlick, R. A. ; Lawley, T. J. / C5a as a mediator of cutaneous inflammation. In: American Journal of Dermatopathology. 1987 ; Vol. 9, No. 2. pp. 138-143.
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