C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1β and interleukin 1α

S. Okusawa, K. B. Yancey, J. W M Van der Meer, S. Endres, G. Lonnemann, K. Hefter, M. M. Frank, J. F. Burke, C. A. Dinarello, J. A. Gelfand

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-α, IL-1β, and IL-1α, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-α and Il-1β secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1α. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.

Original languageEnglish (US)
Pages (from-to)443-448
Number of pages6
JournalJournal of Experimental Medicine
Volume168
Issue number1
StatePublished - 1988

Fingerprint

Interleukin-1
Gram-Negative Bacterial Infections
Immune Complex Diseases
Acute-Phase Proteins
Fever
human TNF protein
In Vitro Techniques
Wounds and Injuries

ASJC Scopus subject areas

  • Immunology

Cite this

C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1β and interleukin 1α. / Okusawa, S.; Yancey, K. B.; Van der Meer, J. W M; Endres, S.; Lonnemann, G.; Hefter, K.; Frank, M. M.; Burke, J. F.; Dinarello, C. A.; Gelfand, J. A.

In: Journal of Experimental Medicine, Vol. 168, No. 1, 1988, p. 443-448.

Research output: Contribution to journalArticle

Okusawa, S, Yancey, KB, Van der Meer, JWM, Endres, S, Lonnemann, G, Hefter, K, Frank, MM, Burke, JF, Dinarello, CA & Gelfand, JA 1988, 'C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1β and interleukin 1α', Journal of Experimental Medicine, vol. 168, no. 1, pp. 443-448.
Okusawa, S. ; Yancey, K. B. ; Van der Meer, J. W M ; Endres, S. ; Lonnemann, G. ; Hefter, K. ; Frank, M. M. ; Burke, J. F. ; Dinarello, C. A. ; Gelfand, J. A. / C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1β and interleukin 1α. In: Journal of Experimental Medicine. 1988 ; Vol. 168, No. 1. pp. 443-448.
@article{baff40773f8e4595a0b993990456e8d4,
title = "C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1β and interleukin 1α",
abstract = "We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-α, IL-1β, and IL-1α, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-α and Il-1β secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1α. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.",
author = "S. Okusawa and Yancey, {K. B.} and {Van der Meer}, {J. W M} and S. Endres and G. Lonnemann and K. Hefter and Frank, {M. M.} and Burke, {J. F.} and Dinarello, {C. A.} and Gelfand, {J. A.}",
year = "1988",
language = "English (US)",
volume = "168",
pages = "443--448",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "1",

}

TY - JOUR

T1 - C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1β and interleukin 1α

AU - Okusawa, S.

AU - Yancey, K. B.

AU - Van der Meer, J. W M

AU - Endres, S.

AU - Lonnemann, G.

AU - Hefter, K.

AU - Frank, M. M.

AU - Burke, J. F.

AU - Dinarello, C. A.

AU - Gelfand, J. A.

PY - 1988

Y1 - 1988

N2 - We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-α, IL-1β, and IL-1α, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-α and Il-1β secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1α. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.

AB - We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-α, IL-1β, and IL-1α, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-α and Il-1β secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1α. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.

UR - http://www.scopus.com/inward/record.url?scp=0023772348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023772348&partnerID=8YFLogxK

M3 - Article

C2 - 3260938

AN - SCOPUS:0023772348

VL - 168

SP - 443

EP - 448

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 1

ER -