We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-α, IL-1β, and IL-1α, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-α and Il-1β secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1α. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Experimental Medicine|
|Publication status||Published - 1988|
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