C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1β and interleukin 1α

S. Okusawa, K. B. Yancey, J. W M Van der Meer, S. Endres, G. Lonnemann, K. Hefter, M. M. Frank, J. F. Burke, C. A. Dinarello, J. A. Gelfand

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Abstract

We have demonstrated that purified C5a is a potent stimulus to human PBMC secretion of TNF-α, IL-1β, and IL-1α, which proceeds in a dose-dependent fashion. At a given concentration of C5a, TNF-α and Il-1β secretion did not differ significantly; both were secreted in significantly greater quantity than IL-1α. Clinical conditions such as Gram-positive and Gram-negative bacterial infections, trauma, and immune complex diseases activate complement. Through the mediation of TNF and IL-1 secreted in response to C5a, these diverse disorders can share common features of fever, coagulopathy, acute phase protein production, and disordered metabolism.

Original languageEnglish (US)
Pages (from-to)443-448
Number of pages6
JournalJournal of Experimental Medicine
Volume168
Issue number1
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Immunology

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