Cachectin and tumour necrosis factor as two sides of the same biological coin

Bruce Beutler, Anthony Cerami

Research output: Contribution to journalArticle

1236 Citations (Scopus)

Abstract

In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

Original languageEnglish (US)
Pages (from-to)584-588
Number of pages5
JournalNature
Volume320
Issue number6063
DOIs
StatePublished - 1986

Fingerprint

Numismatics
Tumor Necrosis Factor-alpha
Cachexia
Shock
Macrophages
Proteins
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Cachectin and tumour necrosis factor as two sides of the same biological coin. / Beutler, Bruce; Cerami, Anthony.

In: Nature, Vol. 320, No. 6063, 1986, p. 584-588.

Research output: Contribution to journalArticle

Beutler, Bruce ; Cerami, Anthony. / Cachectin and tumour necrosis factor as two sides of the same biological coin. In: Nature. 1986 ; Vol. 320, No. 6063. pp. 584-588.
@article{b7e53f3dc1c44161b03cd40141c2c4d6,
title = "Cachectin and tumour necrosis factor as two sides of the same biological coin",
abstract = "In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.",
author = "Bruce Beutler and Anthony Cerami",
year = "1986",
doi = "10.1038/320584a0",
language = "English (US)",
volume = "320",
pages = "584--588",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6063",

}

TY - JOUR

T1 - Cachectin and tumour necrosis factor as two sides of the same biological coin

AU - Beutler, Bruce

AU - Cerami, Anthony

PY - 1986

Y1 - 1986

N2 - In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

AB - In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

UR - http://www.scopus.com/inward/record.url?scp=0022485610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022485610&partnerID=8YFLogxK

U2 - 10.1038/320584a0

DO - 10.1038/320584a0

M3 - Article

C2 - 3010124

AN - SCOPUS:0022485610

VL - 320

SP - 584

EP - 588

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6063

ER -