Cachectin and tumour necrosis factor as two sides of the same biological coin

Bruce Beutler, Anthony Cerami

Research output: Contribution to journalArticle

1246 Scopus citations

Abstract

In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

Original languageEnglish (US)
Pages (from-to)584-588
Number of pages5
JournalNature
Volume320
Issue number6063
DOIs
StatePublished - Dec 1 1986

ASJC Scopus subject areas

  • General

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