Cachectin/TNF production in experimental burns and Pseudomonas infection

M. A. Marano, L. L. Moldawer, Y. Fong, H. Wei, J. Minei, R. Yurt, A. Cerami, S. F. Lowry

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Burn injury and infection result in significant losses of lean tissue. The cytokine cachectin/tumor necrosis factor has been implicated in this process but is not uniformly detected during infection. We sought to determine the relationship between body composition changes and in vivo hepatic levels of pretranslational message for cachectin (messenger RNA) in a burn and infection rodent model. Adult Wistar rats were grouped as follows: (1) freely fed, (2) 30% burn, (3) 30% burn with Pseudomonas aeruginosa infection, (4) pair fed, and (5) 30% burn and infection with recombinant cachectin. Compared with controls or animals only burned, burned and infected rats had a 100% increase in hepatic cachectin messenger RNA content, lost carcass protein, and exhibited muscle loss with sparing of liver mass. Tissue production of cachectin as well as other cytokines may be sufficient to mediate several body composition changes observed in response to injury and infection.

Original languageEnglish (US)
Pages (from-to)1383-1388
Number of pages6
JournalArchives of Surgery
Volume123
Issue number11
StatePublished - 1988

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Pseudomonas Infections
Burns
Tumor Necrosis Factor-alpha
Infection
Body Composition
Liver
Cytokines
Messenger RNA
Muscle Proteins
Wounds and Injuries
Pseudomonas aeruginosa
Wistar Rats
Rodentia

ASJC Scopus subject areas

  • Surgery

Cite this

Marano, M. A., Moldawer, L. L., Fong, Y., Wei, H., Minei, J., Yurt, R., ... Lowry, S. F. (1988). Cachectin/TNF production in experimental burns and Pseudomonas infection. Archives of Surgery, 123(11), 1383-1388.

Cachectin/TNF production in experimental burns and Pseudomonas infection. / Marano, M. A.; Moldawer, L. L.; Fong, Y.; Wei, H.; Minei, J.; Yurt, R.; Cerami, A.; Lowry, S. F.

In: Archives of Surgery, Vol. 123, No. 11, 1988, p. 1383-1388.

Research output: Contribution to journalArticle

Marano, MA, Moldawer, LL, Fong, Y, Wei, H, Minei, J, Yurt, R, Cerami, A & Lowry, SF 1988, 'Cachectin/TNF production in experimental burns and Pseudomonas infection', Archives of Surgery, vol. 123, no. 11, pp. 1383-1388.
Marano MA, Moldawer LL, Fong Y, Wei H, Minei J, Yurt R et al. Cachectin/TNF production in experimental burns and Pseudomonas infection. Archives of Surgery. 1988;123(11):1383-1388.
Marano, M. A. ; Moldawer, L. L. ; Fong, Y. ; Wei, H. ; Minei, J. ; Yurt, R. ; Cerami, A. ; Lowry, S. F. / Cachectin/TNF production in experimental burns and Pseudomonas infection. In: Archives of Surgery. 1988 ; Vol. 123, No. 11. pp. 1383-1388.
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