Calcineurin-dependent ion channel regulation in heart

Yanggan Wang, Samvit Tandan, Joseph A Hill

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Calcineurin, a serine-threonine-specific, Ca2+-calmodulin-activated protein phosphatase, conserved from yeast to humans, plays a key role in regulating cardiac development, hypertrophy, and pathological remodeling. Recent studies demonstrate that calcineurin regulates cardiomyocyte ion channels and receptors in a manner which often entails direct interaction with these target proteins. Here, we review the current state of knowledge of calcineurin-mediated regulation of ion channels in the myocardium with emphasis on the transient outward potassium current (Ito) and L-type calcium current (ICa,L). We go on to discuss unanswered questions that surround these observations and provide perspective on future directions in this exciting field.

Original languageEnglish (US)
Pages (from-to)14-22
Number of pages9
JournalTrends in Cardiovascular Medicine
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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