Calcineurin-dependent ion channel regulation in heart

Yanggan Wang, Samvit Tandan, Joseph A Hill

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Calcineurin, a serine-threonine-specific, Ca2+-calmodulin-activated protein phosphatase, conserved from yeast to humans, plays a key role in regulating cardiac development, hypertrophy, and pathological remodeling. Recent studies demonstrate that calcineurin regulates cardiomyocyte ion channels and receptors in a manner which often entails direct interaction with these target proteins. Here, we review the current state of knowledge of calcineurin-mediated regulation of ion channels in the myocardium with emphasis on the transient outward potassium current (Ito) and L-type calcium current (ICa,L). We go on to discuss unanswered questions that surround these observations and provide perspective on future directions in this exciting field.

Original languageEnglish (US)
Pages (from-to)14-22
Number of pages9
JournalTrends in Cardiovascular Medicine
Volume24
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Calcineurin
Ion Channels
Phosphoprotein Phosphatases
Cardiomegaly
Threonine
Calmodulin
Cardiac Myocytes
Serine
Myocardium
Potassium
Yeasts
Calcium
Proteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Calcineurin-dependent ion channel regulation in heart. / Wang, Yanggan; Tandan, Samvit; Hill, Joseph A.

In: Trends in Cardiovascular Medicine, Vol. 24, No. 1, 01.2014, p. 14-22.

Research output: Contribution to journalArticle

Wang, Yanggan ; Tandan, Samvit ; Hill, Joseph A. / Calcineurin-dependent ion channel regulation in heart. In: Trends in Cardiovascular Medicine. 2014 ; Vol. 24, No. 1. pp. 14-22.
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