Calciphylaxis: Controversies in pathogenesis, diagnosis and treatment

Haneol S. Jeong, Arturo R. Dominguez

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Calcific uremic arteriolopathy, otherwise known as calciphylaxis, is a rare disease characterized by skin ulceration and tissue necrosis, likely the result of vascular calcification with accompanying intimal hypertrophy and small vessel thrombosis. Although most often associated with end-stage renal disease, it has also been seen in a number of other disorders (collectively referred to as nonuremic calciphylaxis). The purpose of this review is to summarize and analyze the currently available literature regarding the pathophysiology, risk factors, clinical presentation, diagnostic features and treatment modalities for this exceptionally uncommon illness. A series of recommended treatments is proposed for optimal treatment of calciphylaxis lesions.

Original languageEnglish (US)
Pages (from-to)217-227
Number of pages11
JournalAmerican Journal of the Medical Sciences
Volume351
Issue number2
DOIs
StatePublished - 2016

Fingerprint

Calciphylaxis
Tunica Intima
Vascular Calcification
Rare Diseases
Hypertrophy
Chronic Kidney Failure
Thrombosis
Necrosis
Skin

Keywords

  • Calcific uremic arteriolopathy
  • Calciphylaxis
  • Diagnosis
  • Pathogenesis
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Calciphylaxis : Controversies in pathogenesis, diagnosis and treatment. / Jeong, Haneol S.; Dominguez, Arturo R.

In: American Journal of the Medical Sciences, Vol. 351, No. 2, 2016, p. 217-227.

Research output: Contribution to journalArticle

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