Calciphylaxis in a dialysis patient diagnosed by muscle biopsy

Kara Stavros, Rajeev Motiwala, Lan Zhou, Fatmir Sejdiu, Susan Shin

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Calciphylaxis is a rare condition seen mostly in patients with chronic renal disease and secondary hyperparathyroidism who develop painful skin lesions and myopathy secondary to extensive small vessel calcification, which leads to tissue ischemia. It is typically diagnosed by a biopsy of prominent skin lesions. Here, we report a 49-year-old man with end-stage renal disease on chronic peritoneal dialysis who presented with weakness, myalgias, and necrotic skin lesions. Multiple skin biopsies were nondiagnostic because of severe extensive necrosis, and the diagnosis of systemic calciphylaxis was eventually made by a muscle biopsy. This case demonstrates the significant muscle involvement in calciphylaxis and highlights the importance of maintaining a high clinical suspicion for patients with risk factors for calciphylaxis, even when skin biopsy does not confirm it.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalJournal of Clinical Neuromuscular Disease
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2014

Fingerprint

Calciphylaxis
Dialysis
Biopsy
Muscles
Skin
Secondary Hyperparathyroidism
Myalgia
Peritoneal Dialysis
Muscular Diseases
Chronic Renal Insufficiency
Chronic Kidney Failure
Necrosis
Ischemia

Keywords

  • calciphylaxis
  • end-stage
  • muscle biopsy
  • myopathy
  • renal disease
  • rhabdomyolysis
  • skin biopsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Calciphylaxis in a dialysis patient diagnosed by muscle biopsy. / Stavros, Kara; Motiwala, Rajeev; Zhou, Lan; Sejdiu, Fatmir; Shin, Susan.

In: Journal of Clinical Neuromuscular Disease, Vol. 15, No. 3, 01.03.2014, p. 108-111.

Research output: Contribution to journalReview article

Stavros, Kara ; Motiwala, Rajeev ; Zhou, Lan ; Sejdiu, Fatmir ; Shin, Susan. / Calciphylaxis in a dialysis patient diagnosed by muscle biopsy. In: Journal of Clinical Neuromuscular Disease. 2014 ; Vol. 15, No. 3. pp. 108-111.
@article{e0b74aff99d54fa296ed0c3f7154362a,
title = "Calciphylaxis in a dialysis patient diagnosed by muscle biopsy",
abstract = "Calciphylaxis is a rare condition seen mostly in patients with chronic renal disease and secondary hyperparathyroidism who develop painful skin lesions and myopathy secondary to extensive small vessel calcification, which leads to tissue ischemia. It is typically diagnosed by a biopsy of prominent skin lesions. Here, we report a 49-year-old man with end-stage renal disease on chronic peritoneal dialysis who presented with weakness, myalgias, and necrotic skin lesions. Multiple skin biopsies were nondiagnostic because of severe extensive necrosis, and the diagnosis of systemic calciphylaxis was eventually made by a muscle biopsy. This case demonstrates the significant muscle involvement in calciphylaxis and highlights the importance of maintaining a high clinical suspicion for patients with risk factors for calciphylaxis, even when skin biopsy does not confirm it.",
keywords = "calciphylaxis, end-stage, muscle biopsy, myopathy, renal disease, rhabdomyolysis, skin biopsy",
author = "Kara Stavros and Rajeev Motiwala and Lan Zhou and Fatmir Sejdiu and Susan Shin",
year = "2014",
month = "3",
day = "1",
doi = "10.1097/CND.0000000000000024",
language = "English (US)",
volume = "15",
pages = "108--111",
journal = "Journal of Clinical Neuromuscular Disease",
issn = "1522-0443",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Calciphylaxis in a dialysis patient diagnosed by muscle biopsy

AU - Stavros, Kara

AU - Motiwala, Rajeev

AU - Zhou, Lan

AU - Sejdiu, Fatmir

AU - Shin, Susan

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Calciphylaxis is a rare condition seen mostly in patients with chronic renal disease and secondary hyperparathyroidism who develop painful skin lesions and myopathy secondary to extensive small vessel calcification, which leads to tissue ischemia. It is typically diagnosed by a biopsy of prominent skin lesions. Here, we report a 49-year-old man with end-stage renal disease on chronic peritoneal dialysis who presented with weakness, myalgias, and necrotic skin lesions. Multiple skin biopsies were nondiagnostic because of severe extensive necrosis, and the diagnosis of systemic calciphylaxis was eventually made by a muscle biopsy. This case demonstrates the significant muscle involvement in calciphylaxis and highlights the importance of maintaining a high clinical suspicion for patients with risk factors for calciphylaxis, even when skin biopsy does not confirm it.

AB - Calciphylaxis is a rare condition seen mostly in patients with chronic renal disease and secondary hyperparathyroidism who develop painful skin lesions and myopathy secondary to extensive small vessel calcification, which leads to tissue ischemia. It is typically diagnosed by a biopsy of prominent skin lesions. Here, we report a 49-year-old man with end-stage renal disease on chronic peritoneal dialysis who presented with weakness, myalgias, and necrotic skin lesions. Multiple skin biopsies were nondiagnostic because of severe extensive necrosis, and the diagnosis of systemic calciphylaxis was eventually made by a muscle biopsy. This case demonstrates the significant muscle involvement in calciphylaxis and highlights the importance of maintaining a high clinical suspicion for patients with risk factors for calciphylaxis, even when skin biopsy does not confirm it.

KW - calciphylaxis

KW - end-stage

KW - muscle biopsy

KW - myopathy

KW - renal disease

KW - rhabdomyolysis

KW - skin biopsy

UR - http://www.scopus.com/inward/record.url?scp=84894468668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894468668&partnerID=8YFLogxK

U2 - 10.1097/CND.0000000000000024

DO - 10.1097/CND.0000000000000024

M3 - Review article

C2 - 24534833

AN - SCOPUS:84894468668

VL - 15

SP - 108

EP - 111

JO - Journal of Clinical Neuromuscular Disease

JF - Journal of Clinical Neuromuscular Disease

SN - 1522-0443

IS - 3

ER -