Calcium-channel blockade in the management of severe chronic congestive heart failure: A bridge too far

M. Packer, P. D. Kessler, Hung Lee Wai Hung Lee

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Because vasodilator therapy has become an established approach to the treatment of patients with severe chronic heart failure, there has been increasing interest in the use of the calcium channel-blocking drugs in the management of this disorder. This approach has particular appeal because approximately 60% of patients with heart failure have severe left ventricular dysfunction associated with coronary artery disease, and left ventricular systolic and diastolic performance in these patients may improve after interventions directed at improving myocardial blood flow. Unfortunately, all available calcium channel-blocking drugs possess potent negative inotropic effects; these are normally offset in patients without heart failure by activation of the sympathetic nervous system. Patients with severe left ventricular dysfunction, however, are exquisitely dependent on the transmembrane transport of calcium for maintenance of contractile function and show marked attenuation of adrenergic reflexes, which can no longer serve a homeostatic support function; hence, such patients are likely to experience notable cardiodepressant effects after calcium-channel blockade. In clinical trials, although some patients with severe chronic heart failure have been reported to benefit from short-term calcium-channel blockade, the hemodynamic benefits seen are modest compared with those from conventional vasodilator drugs, and little long-term improvements has been observed in randomized, double-blind trials. In addition, 10% to 40% of patients who receive short- and long-term therapy with verapamil, nifedipine, and diltiazem show evidence of serious hemodynamic or clinical deterioration. For the patient with severe symptomatic left ventricular dysfunction, a number of conventional vasodilators (that do not have intrinsic negative inotropic actions) are now available that can reliably produce long-term hemodynamic and clinical benefits without serious cardiovascular risks. Such agents are preferred therapy for these individuals; calcium-channel blockade should not be used as primary treatment for this disorder.

Original languageEnglish (US)
JournalCirculation
Volume75
Issue number6 II SUPPL.
StatePublished - 1987

Fingerprint

Calcium Channels
Heart Failure
Left Ventricular Dysfunction
Vasodilator Agents
Hemodynamics
Calcium Channel Blockers
Therapeutics
Diltiazem
Sympathetic Nervous System
Nifedipine
Verapamil
Adrenergic Agents
Reflex
Coronary Artery Disease
Maintenance
Clinical Trials
Calcium

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Packer, M., Kessler, P. D., & Wai Hung Lee, H. L. (1987). Calcium-channel blockade in the management of severe chronic congestive heart failure: A bridge too far. Circulation, 75(6 II SUPPL.).

Calcium-channel blockade in the management of severe chronic congestive heart failure : A bridge too far. / Packer, M.; Kessler, P. D.; Wai Hung Lee, Hung Lee.

In: Circulation, Vol. 75, No. 6 II SUPPL., 1987.

Research output: Contribution to journalArticle

Packer, M, Kessler, PD & Wai Hung Lee, HL 1987, 'Calcium-channel blockade in the management of severe chronic congestive heart failure: A bridge too far', Circulation, vol. 75, no. 6 II SUPPL..
Packer, M. ; Kessler, P. D. ; Wai Hung Lee, Hung Lee. / Calcium-channel blockade in the management of severe chronic congestive heart failure : A bridge too far. In: Circulation. 1987 ; Vol. 75, No. 6 II SUPPL.
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