Calcium citrate: Reduced propensity for the crystallization of calcium oxalate in urine resulting from induced hypercalciuria of calcium supplementation

J. A. Harvey, M. M. Zobitz, C. Y C Pak

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Abstract

The effect of calcium citrate (800 mg calcium/day in 4 divided doses) on urinary biochemistry and crystallization of calcium salts was examined in 18 normal subjects. During treatment, urinary calcium increased significantly (from 150 ± 65 (SD) to 248 ± 77 mg/day). Urinary citrate rose from 611 ± 208 to 730 ± 225 mg/day, owing largely to the alkali load. The urinary saturation of calcium oxalate rose by only 41% during calcium citrate treatment, due mainly to citrate complexation of calcium (rather than by 62% without such complexation). Moreover, the formation product of calcium oxalate rose during treatment, indicating that the enhanced citrate excretion augmented the inhibitor activity against calcium oxalate crystallization. Thus, calcium citrate may not be attendant with the risk for stone formation usually associated with calcium supplementation.

Original languageEnglish (US)
Pages (from-to)1223-1225
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume61
Issue number6
StatePublished - 1985

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Calcium Citrate
Hypercalciuria
Calcium Oxalate
Crystallization
Urine
Calcium
Complexation
Citric Acid
Biochemistry
Alkalies
Salts

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Calcium citrate: Reduced propensity for the crystallization of calcium oxalate in urine resulting from induced hypercalciuria of calcium supplementation",
abstract = "The effect of calcium citrate (800 mg calcium/day in 4 divided doses) on urinary biochemistry and crystallization of calcium salts was examined in 18 normal subjects. During treatment, urinary calcium increased significantly (from 150 ± 65 (SD) to 248 ± 77 mg/day). Urinary citrate rose from 611 ± 208 to 730 ± 225 mg/day, owing largely to the alkali load. The urinary saturation of calcium oxalate rose by only 41{\%} during calcium citrate treatment, due mainly to citrate complexation of calcium (rather than by 62{\%} without such complexation). Moreover, the formation product of calcium oxalate rose during treatment, indicating that the enhanced citrate excretion augmented the inhibitor activity against calcium oxalate crystallization. Thus, calcium citrate may not be attendant with the risk for stone formation usually associated with calcium supplementation.",
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T2 - Reduced propensity for the crystallization of calcium oxalate in urine resulting from induced hypercalciuria of calcium supplementation

AU - Harvey, J. A.

AU - Zobitz, M. M.

AU - Pak, C. Y C

PY - 1985

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N2 - The effect of calcium citrate (800 mg calcium/day in 4 divided doses) on urinary biochemistry and crystallization of calcium salts was examined in 18 normal subjects. During treatment, urinary calcium increased significantly (from 150 ± 65 (SD) to 248 ± 77 mg/day). Urinary citrate rose from 611 ± 208 to 730 ± 225 mg/day, owing largely to the alkali load. The urinary saturation of calcium oxalate rose by only 41% during calcium citrate treatment, due mainly to citrate complexation of calcium (rather than by 62% without such complexation). Moreover, the formation product of calcium oxalate rose during treatment, indicating that the enhanced citrate excretion augmented the inhibitor activity against calcium oxalate crystallization. Thus, calcium citrate may not be attendant with the risk for stone formation usually associated with calcium supplementation.

AB - The effect of calcium citrate (800 mg calcium/day in 4 divided doses) on urinary biochemistry and crystallization of calcium salts was examined in 18 normal subjects. During treatment, urinary calcium increased significantly (from 150 ± 65 (SD) to 248 ± 77 mg/day). Urinary citrate rose from 611 ± 208 to 730 ± 225 mg/day, owing largely to the alkali load. The urinary saturation of calcium oxalate rose by only 41% during calcium citrate treatment, due mainly to citrate complexation of calcium (rather than by 62% without such complexation). Moreover, the formation product of calcium oxalate rose during treatment, indicating that the enhanced citrate excretion augmented the inhibitor activity against calcium oxalate crystallization. Thus, calcium citrate may not be attendant with the risk for stone formation usually associated with calcium supplementation.

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