Calcium-independent phospholipases in the heart: Mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction

Ari Cedars, Christopher M. Jenkins, David J. Mancuso, Richard W. Gross

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Myocardial function is intimately dependent on the precise spatiotemporal regulation of membrane-bound proteins and ion channels. Phospholipases play critical roles in the maintenance of membrane structure and function, thereby fundamentally integrating dynamic alterations in myocardial performance with membrane composition and dynamics. The major phospholipases in myocardium belong to a family of proteins known as calcium-independent phospholipases (iPLA2s). In addition to their role in maintaining normal membrane structure and function, iPLA2 catalytic activity results in the generation of a variety of lipid second messengers that facilitate cellular signaling. Through its multiple effects on cardiac myocyte bioenergetics, cellular signaling, and membrane function, the iPLA2 family of enzymes is of primary importance in modulating the pathologic sequelae of myocardial ischemia, diabetic cardiomyopathy, and remodeling during hemodynamic stress. This review will provide a brief overview of myocardial iPLA2s and their significance in cardiac pathology and physiology.

Original languageEnglish (US)
Pages (from-to)277-289
Number of pages13
JournalJournal of Cardiovascular Pharmacology
Volume53
Issue number4
StatePublished - Apr 1 2009
Externally publishedYes

Fingerprint

Phospholipases
Energy Metabolism
Ischemia
Calcium
Membranes
Diabetic Cardiomyopathies
Second Messenger Systems
Ion Channels
Cardiac Myocytes
Myocardial Ischemia
Myocardium
Membrane Proteins
Hemodynamics
Maintenance
Pathology
Lipids
Enzymes
Proteins

Keywords

  • Arrhythmia
  • Cardiomyopathy
  • Cell membrane
  • Diabetes
  • Ion channels
  • Ischemia
  • Mitochondria
  • Myocardium
  • Phospholipase

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Calcium-independent phospholipases in the heart : Mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction. / Cedars, Ari; Jenkins, Christopher M.; Mancuso, David J.; Gross, Richard W.

In: Journal of Cardiovascular Pharmacology, Vol. 53, No. 4, 01.04.2009, p. 277-289.

Research output: Contribution to journalReview article

@article{c863ba3f43cb4749abaf2ca142a7c9ed,
title = "Calcium-independent phospholipases in the heart: Mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction",
abstract = "Myocardial function is intimately dependent on the precise spatiotemporal regulation of membrane-bound proteins and ion channels. Phospholipases play critical roles in the maintenance of membrane structure and function, thereby fundamentally integrating dynamic alterations in myocardial performance with membrane composition and dynamics. The major phospholipases in myocardium belong to a family of proteins known as calcium-independent phospholipases (iPLA2s). In addition to their role in maintaining normal membrane structure and function, iPLA2 catalytic activity results in the generation of a variety of lipid second messengers that facilitate cellular signaling. Through its multiple effects on cardiac myocyte bioenergetics, cellular signaling, and membrane function, the iPLA2 family of enzymes is of primary importance in modulating the pathologic sequelae of myocardial ischemia, diabetic cardiomyopathy, and remodeling during hemodynamic stress. This review will provide a brief overview of myocardial iPLA2s and their significance in cardiac pathology and physiology.",
keywords = "Arrhythmia, Cardiomyopathy, Cell membrane, Diabetes, Ion channels, Ischemia, Mitochondria, Myocardium, Phospholipase",
author = "Ari Cedars and Jenkins, {Christopher M.} and Mancuso, {David J.} and Gross, {Richard W.}",
year = "2009",
month = "4",
day = "1",
language = "English (US)",
volume = "53",
pages = "277--289",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Calcium-independent phospholipases in the heart

T2 - Mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction

AU - Cedars, Ari

AU - Jenkins, Christopher M.

AU - Mancuso, David J.

AU - Gross, Richard W.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Myocardial function is intimately dependent on the precise spatiotemporal regulation of membrane-bound proteins and ion channels. Phospholipases play critical roles in the maintenance of membrane structure and function, thereby fundamentally integrating dynamic alterations in myocardial performance with membrane composition and dynamics. The major phospholipases in myocardium belong to a family of proteins known as calcium-independent phospholipases (iPLA2s). In addition to their role in maintaining normal membrane structure and function, iPLA2 catalytic activity results in the generation of a variety of lipid second messengers that facilitate cellular signaling. Through its multiple effects on cardiac myocyte bioenergetics, cellular signaling, and membrane function, the iPLA2 family of enzymes is of primary importance in modulating the pathologic sequelae of myocardial ischemia, diabetic cardiomyopathy, and remodeling during hemodynamic stress. This review will provide a brief overview of myocardial iPLA2s and their significance in cardiac pathology and physiology.

AB - Myocardial function is intimately dependent on the precise spatiotemporal regulation of membrane-bound proteins and ion channels. Phospholipases play critical roles in the maintenance of membrane structure and function, thereby fundamentally integrating dynamic alterations in myocardial performance with membrane composition and dynamics. The major phospholipases in myocardium belong to a family of proteins known as calcium-independent phospholipases (iPLA2s). In addition to their role in maintaining normal membrane structure and function, iPLA2 catalytic activity results in the generation of a variety of lipid second messengers that facilitate cellular signaling. Through its multiple effects on cardiac myocyte bioenergetics, cellular signaling, and membrane function, the iPLA2 family of enzymes is of primary importance in modulating the pathologic sequelae of myocardial ischemia, diabetic cardiomyopathy, and remodeling during hemodynamic stress. This review will provide a brief overview of myocardial iPLA2s and their significance in cardiac pathology and physiology.

KW - Arrhythmia

KW - Cardiomyopathy

KW - Cell membrane

KW - Diabetes

KW - Ion channels

KW - Ischemia

KW - Mitochondria

KW - Myocardium

KW - Phospholipase

UR - http://www.scopus.com/inward/record.url?scp=67650354215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650354215&partnerID=8YFLogxK

M3 - Review article

C2 - 19390346

AN - SCOPUS:67650354215

VL - 53

SP - 277

EP - 289

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 4

ER -