Calculation of radiation dose enhancement factors for dose enhancement therapy of brain tumours

T. D. Solberg, K. S. Iwamoto, A. Norman

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

When brain tumours are loaded with iodinated contrast media (CM) and exposed to X-rays, the photoelectrons, Auger electrons and fluorescent X-rays from the iodine enhance the radiation dose absorbed by the tumour. A modified CT scanner, the CTX, can be used to localize the tumour and to deliver the dose enhancement therapy. Monte Carlo calculations are presented of the central-axis radiation depth dose in a brain containing a tumour loaded with an iodine concentration of 5 mg ml-1 and irradiated with the CTX operated at various kV settings. The dose enhancement factor (DEF) is also calculated for various field sizes and for 5 mg ml-1 of gadolinium in the tumour when the CTX is operated at 140 kV. The calculated values of the DEF are close to published experimental results.

Original languageEnglish (US)
Article number010
Pages (from-to)439-443
Number of pages5
JournalPhysics in Medicine and Biology
Volume37
Issue number2
DOIs
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy (miscellaneous)
  • Biomedical Engineering

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