Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes

Alan N. Francis, Suraj S. Mothi, Ian T. Mathew, Neeraj Tandon, Brett Clementz, Godfrey D. Pearlson, John A. Sweeney, Carol A. Tamminga, Matcheri S. Keshavan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The corpus callosum has been implicated in the pathogenesis of schizophrenia and bipolar disorder. However, it is unclear whether corpus callosum alterations are related to the underlying familial diathesis for psychotic disorders. We examined the corpus callosum and its subregion volumes and their relationship to cognition, psychotic symptoms, and age in probands with schizophrenia (SZ), psychotic bipolar disorder (PBD), and schizoaffective disorder; their first-degree relatives; and healthy control subjects. Methods: We present findings from morphometric and neurocognitive analyses of 1381 subjects (SZ probands, n = 224; PBD probands, n = 190; schizoaffective disorder probands, n = 142; unaffected relatives, n = 483 [SZ relatives, n = 195; PBD relatives, n = 175; schizoaffective disorder relatives, n = 113]; control subjects, n = 342). Magnetization prepared rapid acquisition gradient-echo T1 scans across five sites were obtained using 3-tesla magnets. Image processing was done using FreeSurfer Version 5.1. Neurocognitive function was measured using the Brief Assessment of Cognition in Schizophrenia scale. Results: Anterior and posterior splenial volumes were significantly reduced across the groups. The SZ and PBD probands showed robust and significant reductions, whereas relatives showed significant reductions of intermediate severity. The splenial volumes were positively but differentially correlated with aspects of cognition in the probands and their relatives. Proband groups showed a significant age-related decrease in the volume of the anterior splenium compared with control subjects. Among the psychosis groups, the anterior splenium in probands with PBD showed a stronger correlation with psychotic symptoms, as shown by the Positive and Negative Syndrome Scale. All five subregions showed significantly high familiality. Conclusions: The splenial volumes were significantly reduced across the psychosis dimension. However, this volume reduction impacts cognition and clinical manifestation of the illnesses differentially.

Original languageEnglish (US)
JournalBiological Psychiatry
DOIs
StateAccepted/In press - Apr 10 2015

Fingerprint

Corpus Callosum
Psychotic Disorders
Schizophrenia
Phenotype
Bipolar Disorder
Cognition
Magnets
Disease Susceptibility
Healthy Volunteers

Keywords

  • Bipolar
  • Corpus callosum
  • Neuroimaging
  • Psychosis
  • Schizoaffective
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Francis, A. N., Mothi, S. S., Mathew, I. T., Tandon, N., Clementz, B., Pearlson, G. D., ... Keshavan, M. S. (Accepted/In press). Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2015.12.026

Callosal Abnormalities Across the Psychosis Dimension : Bipolar Schizophrenia Network on Intermediate Phenotypes. / Francis, Alan N.; Mothi, Suraj S.; Mathew, Ian T.; Tandon, Neeraj; Clementz, Brett; Pearlson, Godfrey D.; Sweeney, John A.; Tamminga, Carol A.; Keshavan, Matcheri S.

In: Biological Psychiatry, 10.04.2015.

Research output: Contribution to journalArticle

Francis, Alan N. ; Mothi, Suraj S. ; Mathew, Ian T. ; Tandon, Neeraj ; Clementz, Brett ; Pearlson, Godfrey D. ; Sweeney, John A. ; Tamminga, Carol A. ; Keshavan, Matcheri S. / Callosal Abnormalities Across the Psychosis Dimension : Bipolar Schizophrenia Network on Intermediate Phenotypes. In: Biological Psychiatry. 2015.
@article{96123b0a7f504bc4857b50ad1f4b156b,
title = "Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes",
abstract = "Background: The corpus callosum has been implicated in the pathogenesis of schizophrenia and bipolar disorder. However, it is unclear whether corpus callosum alterations are related to the underlying familial diathesis for psychotic disorders. We examined the corpus callosum and its subregion volumes and their relationship to cognition, psychotic symptoms, and age in probands with schizophrenia (SZ), psychotic bipolar disorder (PBD), and schizoaffective disorder; their first-degree relatives; and healthy control subjects. Methods: We present findings from morphometric and neurocognitive analyses of 1381 subjects (SZ probands, n = 224; PBD probands, n = 190; schizoaffective disorder probands, n = 142; unaffected relatives, n = 483 [SZ relatives, n = 195; PBD relatives, n = 175; schizoaffective disorder relatives, n = 113]; control subjects, n = 342). Magnetization prepared rapid acquisition gradient-echo T1 scans across five sites were obtained using 3-tesla magnets. Image processing was done using FreeSurfer Version 5.1. Neurocognitive function was measured using the Brief Assessment of Cognition in Schizophrenia scale. Results: Anterior and posterior splenial volumes were significantly reduced across the groups. The SZ and PBD probands showed robust and significant reductions, whereas relatives showed significant reductions of intermediate severity. The splenial volumes were positively but differentially correlated with aspects of cognition in the probands and their relatives. Proband groups showed a significant age-related decrease in the volume of the anterior splenium compared with control subjects. Among the psychosis groups, the anterior splenium in probands with PBD showed a stronger correlation with psychotic symptoms, as shown by the Positive and Negative Syndrome Scale. All five subregions showed significantly high familiality. Conclusions: The splenial volumes were significantly reduced across the psychosis dimension. However, this volume reduction impacts cognition and clinical manifestation of the illnesses differentially.",
keywords = "Bipolar, Corpus callosum, Neuroimaging, Psychosis, Schizoaffective, Schizophrenia",
author = "Francis, {Alan N.} and Mothi, {Suraj S.} and Mathew, {Ian T.} and Neeraj Tandon and Brett Clementz and Pearlson, {Godfrey D.} and Sweeney, {John A.} and Tamminga, {Carol A.} and Keshavan, {Matcheri S.}",
year = "2015",
month = "4",
day = "10",
doi = "10.1016/j.biopsych.2015.12.026",
language = "English (US)",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",

}

TY - JOUR

T1 - Callosal Abnormalities Across the Psychosis Dimension

T2 - Bipolar Schizophrenia Network on Intermediate Phenotypes

AU - Francis, Alan N.

AU - Mothi, Suraj S.

AU - Mathew, Ian T.

AU - Tandon, Neeraj

AU - Clementz, Brett

AU - Pearlson, Godfrey D.

AU - Sweeney, John A.

AU - Tamminga, Carol A.

AU - Keshavan, Matcheri S.

PY - 2015/4/10

Y1 - 2015/4/10

N2 - Background: The corpus callosum has been implicated in the pathogenesis of schizophrenia and bipolar disorder. However, it is unclear whether corpus callosum alterations are related to the underlying familial diathesis for psychotic disorders. We examined the corpus callosum and its subregion volumes and their relationship to cognition, psychotic symptoms, and age in probands with schizophrenia (SZ), psychotic bipolar disorder (PBD), and schizoaffective disorder; their first-degree relatives; and healthy control subjects. Methods: We present findings from morphometric and neurocognitive analyses of 1381 subjects (SZ probands, n = 224; PBD probands, n = 190; schizoaffective disorder probands, n = 142; unaffected relatives, n = 483 [SZ relatives, n = 195; PBD relatives, n = 175; schizoaffective disorder relatives, n = 113]; control subjects, n = 342). Magnetization prepared rapid acquisition gradient-echo T1 scans across five sites were obtained using 3-tesla magnets. Image processing was done using FreeSurfer Version 5.1. Neurocognitive function was measured using the Brief Assessment of Cognition in Schizophrenia scale. Results: Anterior and posterior splenial volumes were significantly reduced across the groups. The SZ and PBD probands showed robust and significant reductions, whereas relatives showed significant reductions of intermediate severity. The splenial volumes were positively but differentially correlated with aspects of cognition in the probands and their relatives. Proband groups showed a significant age-related decrease in the volume of the anterior splenium compared with control subjects. Among the psychosis groups, the anterior splenium in probands with PBD showed a stronger correlation with psychotic symptoms, as shown by the Positive and Negative Syndrome Scale. All five subregions showed significantly high familiality. Conclusions: The splenial volumes were significantly reduced across the psychosis dimension. However, this volume reduction impacts cognition and clinical manifestation of the illnesses differentially.

AB - Background: The corpus callosum has been implicated in the pathogenesis of schizophrenia and bipolar disorder. However, it is unclear whether corpus callosum alterations are related to the underlying familial diathesis for psychotic disorders. We examined the corpus callosum and its subregion volumes and their relationship to cognition, psychotic symptoms, and age in probands with schizophrenia (SZ), psychotic bipolar disorder (PBD), and schizoaffective disorder; their first-degree relatives; and healthy control subjects. Methods: We present findings from morphometric and neurocognitive analyses of 1381 subjects (SZ probands, n = 224; PBD probands, n = 190; schizoaffective disorder probands, n = 142; unaffected relatives, n = 483 [SZ relatives, n = 195; PBD relatives, n = 175; schizoaffective disorder relatives, n = 113]; control subjects, n = 342). Magnetization prepared rapid acquisition gradient-echo T1 scans across five sites were obtained using 3-tesla magnets. Image processing was done using FreeSurfer Version 5.1. Neurocognitive function was measured using the Brief Assessment of Cognition in Schizophrenia scale. Results: Anterior and posterior splenial volumes were significantly reduced across the groups. The SZ and PBD probands showed robust and significant reductions, whereas relatives showed significant reductions of intermediate severity. The splenial volumes were positively but differentially correlated with aspects of cognition in the probands and their relatives. Proband groups showed a significant age-related decrease in the volume of the anterior splenium compared with control subjects. Among the psychosis groups, the anterior splenium in probands with PBD showed a stronger correlation with psychotic symptoms, as shown by the Positive and Negative Syndrome Scale. All five subregions showed significantly high familiality. Conclusions: The splenial volumes were significantly reduced across the psychosis dimension. However, this volume reduction impacts cognition and clinical manifestation of the illnesses differentially.

KW - Bipolar

KW - Corpus callosum

KW - Neuroimaging

KW - Psychosis

KW - Schizoaffective

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84959478255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959478255&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2015.12.026

DO - 10.1016/j.biopsych.2015.12.026

M3 - Article

C2 - 26954565

AN - SCOPUS:84959478255

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

ER -