CAMCOG as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education

Paula V. Nunes, Breno S. Diniz, Marcia Radanovic, Izabella D. Abreu, Danilo T. Borelli, Monica S. Yassuda, Orestes V. Forlenza

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: The CAMCOG is a brief neuropsychological battery designed to assess global cognitive function and ascertain the impairments that are required for the diagnosis of dementia. To date, the cut-off scores for mild cognitive impairment (MCI) have not been determined. Given the need for an earlier diagnosis of mild dementia, new cut-off values are also necessary, taking into account cultural and educational effects. Methods: One hundred and fifty-seven older adults (mean age: 69.6±7.4 years) with 8 or more years of formal education (mean years of schooling 14.2±3.8) attending a memory clinic at the Institute of Psychiatry University of Sao Paulo were included. Subjects were divided into three groups according to their cognitive status, established through clinical and neuropsychological assessment: normal controls, n=62; MCI, n=65; and mild or moderate dementia, n=30. ROC curve analyses were performed for dementia vs controls, MCI vs controls and MCI vs dementia. Results: The cut-off values were: 92/93 for dementia vs controls (AUC=0.99: sensitivity: 100%, specificity: 95%); 95/96 for MCI vs controls (AUC=0.83, sensitivity: 64%, specificity: 88%), and 85/86 for MCI vs dementia (AUC=0.91, sensitivity: 81%, specificity: 88%). The total CAMCOG score was more accurate than its subtests Mini-mental State Examination, Verbal Fluency Test and Clock Drawing Test when used separately. Conclusions: The CAMCOG discriminated controls and MCI from demented patients, but was less accurate to discriminate MCI from controls. The best cut-off value to differentiate controls and demented was higher than suggested in the original publication, probably because only cases of mild to moderate dementia were included. This is important given the need for a diagnostic at earlier stages of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)1127-1133
Number of pages7
JournalInternational Journal of Geriatric Psychiatry
Volume23
Issue number11
DOIs
StatePublished - Dec 1 2008

Fingerprint

Dementia
Education
Area Under Curve
Sensitivity and Specificity
ROC Curve
Cognitive Dysfunction
Cognition
Psychiatry
Publications
Early Diagnosis
Alzheimer Disease

Keywords

  • Alzheimer's disease
  • Clock Drawing Test
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

CAMCOG as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education. / Nunes, Paula V.; Diniz, Breno S.; Radanovic, Marcia; Abreu, Izabella D.; Borelli, Danilo T.; Yassuda, Monica S.; Forlenza, Orestes V.

In: International Journal of Geriatric Psychiatry, Vol. 23, No. 11, 01.12.2008, p. 1127-1133.

Research output: Contribution to journalArticle

Nunes, Paula V. ; Diniz, Breno S. ; Radanovic, Marcia ; Abreu, Izabella D. ; Borelli, Danilo T. ; Yassuda, Monica S. ; Forlenza, Orestes V. / CAMCOG as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education. In: International Journal of Geriatric Psychiatry. 2008 ; Vol. 23, No. 11. pp. 1127-1133.
@article{627a1ee5461d4a8699c0f38412bd4708,
title = "CAMCOG as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education",
abstract = "Background: The CAMCOG is a brief neuropsychological battery designed to assess global cognitive function and ascertain the impairments that are required for the diagnosis of dementia. To date, the cut-off scores for mild cognitive impairment (MCI) have not been determined. Given the need for an earlier diagnosis of mild dementia, new cut-off values are also necessary, taking into account cultural and educational effects. Methods: One hundred and fifty-seven older adults (mean age: 69.6±7.4 years) with 8 or more years of formal education (mean years of schooling 14.2±3.8) attending a memory clinic at the Institute of Psychiatry University of Sao Paulo were included. Subjects were divided into three groups according to their cognitive status, established through clinical and neuropsychological assessment: normal controls, n=62; MCI, n=65; and mild or moderate dementia, n=30. ROC curve analyses were performed for dementia vs controls, MCI vs controls and MCI vs dementia. Results: The cut-off values were: 92/93 for dementia vs controls (AUC=0.99: sensitivity: 100{\%}, specificity: 95{\%}); 95/96 for MCI vs controls (AUC=0.83, sensitivity: 64{\%}, specificity: 88{\%}), and 85/86 for MCI vs dementia (AUC=0.91, sensitivity: 81{\%}, specificity: 88{\%}). The total CAMCOG score was more accurate than its subtests Mini-mental State Examination, Verbal Fluency Test and Clock Drawing Test when used separately. Conclusions: The CAMCOG discriminated controls and MCI from demented patients, but was less accurate to discriminate MCI from controls. The best cut-off value to differentiate controls and demented was higher than suggested in the original publication, probably because only cases of mild to moderate dementia were included. This is important given the need for a diagnostic at earlier stages of Alzheimer's disease.",
keywords = "Alzheimer's disease, Clock Drawing Test, Mild cognitive impairment",
author = "Nunes, {Paula V.} and Diniz, {Breno S.} and Marcia Radanovic and Abreu, {Izabella D.} and Borelli, {Danilo T.} and Yassuda, {Monica S.} and Forlenza, {Orestes V.}",
year = "2008",
month = "12",
day = "1",
doi = "10.1002/gps.2038",
language = "English (US)",
volume = "23",
pages = "1127--1133",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "John Wiley and Sons Ltd",
number = "11",

}

TY - JOUR

T1 - CAMCOG as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education

AU - Nunes, Paula V.

AU - Diniz, Breno S.

AU - Radanovic, Marcia

AU - Abreu, Izabella D.

AU - Borelli, Danilo T.

AU - Yassuda, Monica S.

AU - Forlenza, Orestes V.

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Background: The CAMCOG is a brief neuropsychological battery designed to assess global cognitive function and ascertain the impairments that are required for the diagnosis of dementia. To date, the cut-off scores for mild cognitive impairment (MCI) have not been determined. Given the need for an earlier diagnosis of mild dementia, new cut-off values are also necessary, taking into account cultural and educational effects. Methods: One hundred and fifty-seven older adults (mean age: 69.6±7.4 years) with 8 or more years of formal education (mean years of schooling 14.2±3.8) attending a memory clinic at the Institute of Psychiatry University of Sao Paulo were included. Subjects were divided into three groups according to their cognitive status, established through clinical and neuropsychological assessment: normal controls, n=62; MCI, n=65; and mild or moderate dementia, n=30. ROC curve analyses were performed for dementia vs controls, MCI vs controls and MCI vs dementia. Results: The cut-off values were: 92/93 for dementia vs controls (AUC=0.99: sensitivity: 100%, specificity: 95%); 95/96 for MCI vs controls (AUC=0.83, sensitivity: 64%, specificity: 88%), and 85/86 for MCI vs dementia (AUC=0.91, sensitivity: 81%, specificity: 88%). The total CAMCOG score was more accurate than its subtests Mini-mental State Examination, Verbal Fluency Test and Clock Drawing Test when used separately. Conclusions: The CAMCOG discriminated controls and MCI from demented patients, but was less accurate to discriminate MCI from controls. The best cut-off value to differentiate controls and demented was higher than suggested in the original publication, probably because only cases of mild to moderate dementia were included. This is important given the need for a diagnostic at earlier stages of Alzheimer's disease.

AB - Background: The CAMCOG is a brief neuropsychological battery designed to assess global cognitive function and ascertain the impairments that are required for the diagnosis of dementia. To date, the cut-off scores for mild cognitive impairment (MCI) have not been determined. Given the need for an earlier diagnosis of mild dementia, new cut-off values are also necessary, taking into account cultural and educational effects. Methods: One hundred and fifty-seven older adults (mean age: 69.6±7.4 years) with 8 or more years of formal education (mean years of schooling 14.2±3.8) attending a memory clinic at the Institute of Psychiatry University of Sao Paulo were included. Subjects were divided into three groups according to their cognitive status, established through clinical and neuropsychological assessment: normal controls, n=62; MCI, n=65; and mild or moderate dementia, n=30. ROC curve analyses were performed for dementia vs controls, MCI vs controls and MCI vs dementia. Results: The cut-off values were: 92/93 for dementia vs controls (AUC=0.99: sensitivity: 100%, specificity: 95%); 95/96 for MCI vs controls (AUC=0.83, sensitivity: 64%, specificity: 88%), and 85/86 for MCI vs dementia (AUC=0.91, sensitivity: 81%, specificity: 88%). The total CAMCOG score was more accurate than its subtests Mini-mental State Examination, Verbal Fluency Test and Clock Drawing Test when used separately. Conclusions: The CAMCOG discriminated controls and MCI from demented patients, but was less accurate to discriminate MCI from controls. The best cut-off value to differentiate controls and demented was higher than suggested in the original publication, probably because only cases of mild to moderate dementia were included. This is important given the need for a diagnostic at earlier stages of Alzheimer's disease.

KW - Alzheimer's disease

KW - Clock Drawing Test

KW - Mild cognitive impairment

UR - http://www.scopus.com/inward/record.url?scp=54049085880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54049085880&partnerID=8YFLogxK

U2 - 10.1002/gps.2038

DO - 10.1002/gps.2038

M3 - Article

C2 - 18464287

AN - SCOPUS:54049085880

VL - 23

SP - 1127

EP - 1133

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 11

ER -