Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia

Roger G. Linington, Marilyn Robertson, Annick Gauthier, B. Brett Finlay, John B. MacMillan, Tadeusz F. Molinski, Rob Van Soest, Raymond J. Andersen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A screening program aimed at discovering inhibitors of the bacterial type III secretion system identified the MeOH extract of the Caribbean sponge Caminus sphaeroconia as an active hit in the initial assay. Bioassay-guided fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalJournal of Natural Products
Volume69
Issue number2
DOIs
StatePublished - Feb 2006

Fingerprint

Spectroscopic analysis
Bioassay
glycolipids
Glycolipids
Porifera
Fractionation
Complex Mixtures
Biological Assay
Assays
Screening
anti-infective agents
type III secretion system
extracts
fractionation
bioassays
screening
assays
Type III Secretion Systems
caminoside A
caminoside B

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Linington, R. G., Robertson, M., Gauthier, A., Finlay, B. B., MacMillan, J. B., Molinski, T. F., ... Andersen, R. J. (2006). Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia. Journal of Natural Products, 69(2), 173-177. https://doi.org/10.1021/np050192h

Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia. / Linington, Roger G.; Robertson, Marilyn; Gauthier, Annick; Finlay, B. Brett; MacMillan, John B.; Molinski, Tadeusz F.; Van Soest, Rob; Andersen, Raymond J.

In: Journal of Natural Products, Vol. 69, No. 2, 02.2006, p. 173-177.

Research output: Contribution to journalArticle

Linington, RG, Robertson, M, Gauthier, A, Finlay, BB, MacMillan, JB, Molinski, TF, Van Soest, R & Andersen, RJ 2006, 'Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia', Journal of Natural Products, vol. 69, no. 2, pp. 173-177. https://doi.org/10.1021/np050192h
Linington, Roger G. ; Robertson, Marilyn ; Gauthier, Annick ; Finlay, B. Brett ; MacMillan, John B. ; Molinski, Tadeusz F. ; Van Soest, Rob ; Andersen, Raymond J. / Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia. In: Journal of Natural Products. 2006 ; Vol. 69, No. 2. pp. 173-177.
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