Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia

Roger G. Linington, Marilyn Robertson, Annick Gauthier, B. Brett Finlay, John B. MacMillan, Tadeusz F. Molinski, Rob Van Soest, Raymond J. Andersen

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

A screening program aimed at discovering inhibitors of the bacterial type III secretion system identified the MeOH extract of the Caribbean sponge Caminus sphaeroconia as an active hit in the initial assay. Bioassay-guided fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalJournal of Natural Products
Volume69
Issue number2
DOIs
StatePublished - Feb 1 2006

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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