Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma?

Justin B. Wenger, Napoleon Santos, Yanxia Liu, Jennifer Dallas, Sukanthini Subbiah, Steven Hochwald, Emina H. Huang, Duyen T. Dang, Carmen J. Allegra, Hendrik Luesch, Long H. Dang

Research output: Contribution to journalReview articlepeer-review

Abstract

Antiangiogenic therapy has shown promise in the treatment of patients with hepatocellular carcinoma (HCC). Bevacizumab, sorafenib, and sunitinib showed efficacy in patients with HCC; and sorafenib is approved by the FDA for treatment of this cancer. In practice, the clinical benefit of these agents has been heterogeneous; and in patients who do respond, the benefit is modest and/or short-lived. Recent advances in the molecular understanding of tumor angiogenesis along with the rapid development of targeted drug discovery have made it possible to explore novel combination therapy for HCC. We review the clinical trial results, discuss possible molecular mechanisms of resistance, and suggest novel combinations with antiangiogenic therapy.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalOncology Reviews
Volume5
Issue number3
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • Antiangiogenic therapy
  • Hepatocellular carcinoma
  • HIF-1α
  • HIF-2α

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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