Cancer cell exosomes can initiate malignant cell transformation

Karoliina Stefanius, Kelly A. Servage, Marcela de Souza Santos, Jason Toombs, Hillery Fields Gray, Suneeta Chimalapati, Min S. Kim, Rolf A. Brekken, Kim Orth

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer evolves through a multistep process that occurs by the temporal accumulation of genetic mutations mediated by intracellular and extracellular cues. We observe that exosomes isolated from pancreatic cancer cells, but not normal pancreatic cells, can initiate the first step of malignant cell transformation. Injection of exosome-initiated transformed cells into mice results in aggressive tumor growth. Using proteomic profiling and DNA sequencing of exosome-treated and transformed cells, we show that cancer cell exosomes act as a classic initiator by causing random genetic changes in recipient cells. Our studies provide new insight into a function of cancer cell exosomes and how they might specifically contribute to orchestrated local cell transformation. One Sentence Summary Exosomes function as an initiator of tumor formation.

Original languageEnglish (US)
JournalUnknown Journal
DOIs
StatePublished - Jul 3 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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