TY - JOUR
T1 - Cancer Chemotherapy II
T2 - Atypical Hepatic Injuries
AU - Rodriguez-Frias, Edmundo A.
AU - Lee, William M.
PY - 2007/8
Y1 - 2007/8
N2 - Although chemotherapy generally is accompanied by regular testing for liver enzyme abnormalities, atypical reactions may occur that escape ordinary detection, because hepatocyte injury is not the primary event. The presence of fatty liver, mitochondrial changes, and even biliary abnormalities can be associated with normal or nearly normal liver enzyme levels. This article discusses unique aspects of liver damage associated with cancer chemotherapy. These unique reactions merit special attention and a special vigilance from clinicians.
AB - Although chemotherapy generally is accompanied by regular testing for liver enzyme abnormalities, atypical reactions may occur that escape ordinary detection, because hepatocyte injury is not the primary event. The presence of fatty liver, mitochondrial changes, and even biliary abnormalities can be associated with normal or nearly normal liver enzyme levels. This article discusses unique aspects of liver damage associated with cancer chemotherapy. These unique reactions merit special attention and a special vigilance from clinicians.
UR - http://www.scopus.com/inward/record.url?scp=34548113537&partnerID=8YFLogxK
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U2 - 10.1016/j.cld.2007.06.012
DO - 10.1016/j.cld.2007.06.012
M3 - Review article
C2 - 17723925
AN - SCOPUS:34548113537
SN - 1089-3261
VL - 11
SP - 663
EP - 676
JO - Clinics in Liver Disease
JF - Clinics in Liver Disease
IS - 3
ER -