Cancer dormancy: From mice to man

Radu Marches, Richard Scheuermann, Jonathan Uhr

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

In this review, we focused on our studies of cancer dormancy in a murine B cell lymphoma and human breast cancer. Lifelong dormancy was induced in syngeneic mice by prior immunization to the idiotype of the tumor cell (TC) Ig before TC challenge. The mice maintained approximately 106 lymphoma cells in their spleen throughout their lifetime despite replication of the TCs at a reduced rate. Recurrences occurred randomly. Because of the balance between replication and cell death, we hypothesized that a similar balance might occur in long-term survivors of breast cancer when the risk of recurrences is very low. We developed a sensitive assay for circulating tumor cells (CTCs) which none were found in normal age-matched women. One third of patients, 7-22 years after mastectomy and without any evidence of disease, had CTCs. The half-life of these CTCs could be deduced from other studies as probably 2-3 hours. Hence, there was a precise balance between replication of TCs (presumably from micrometastases) and cell death. Therefore, a major population of clinically cured breast cancer patients have a chronic disease controlled by their own physiological mechanisms. We speculate on underlying mechanisms based both on studies in experimental models and clinical trials.

Original languageEnglish (US)
Pages (from-to)1772-1778
Number of pages7
JournalCell Cycle
Volume5
Issue number16
DOIs
StatePublished - Aug 15 2006

Keywords

  • Balanced replication
  • Cancer dormancy
  • Cell cycle arrest
  • Circulating tumor cells
  • Idiotype

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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    Marches, R., Scheuermann, R., & Uhr, J. (2006). Cancer dormancy: From mice to man. Cell Cycle, 5(16), 1772-1778. https://doi.org/10.4161/cc.5.16.2995