Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota

Arthur E Frankel, Sachin Deshmukh, Amit Reddy, John Lightcap, Maureen Hayes, Steven McClellan, Seema Singh, Brooks Rabideau, T. Grant Glover, Bruce Roberts, Andrew Koh

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The past decade has seen tremendous advances in both our understanding of cancer immunosuppressive microenvironments and colonic bacteria facilitated by immune checkpoint inhibitor antibodies and next generation sequencing, respectively. Because an important role of the host immune system is to communicate with and regulate the gut microbial community, it should not come as a surprise that the behavior of one is coupled to the other. In this review, we will attempt to dissect some of the studies demonstrating cancer immunotherapy modulation by specific gut microbes and discuss possible molecular mechanisms for this effect.

Original languageEnglish (US)
JournalIntegrative Cancer Therapies
Volume18
DOIs
StatePublished - Apr 1 2019

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Tumor Microenvironment
Immunosuppressive Agents
Immunotherapy
Immune System
Bacteria
Antibodies
Neoplasms
Therapeutics
Gastrointestinal Microbiome

Keywords

  • cancer
  • cytotoxic T-lymphocytes
  • dendritic cells
  • gut microbiota
  • immune checkpoint inhibitor therapy

ASJC Scopus subject areas

  • Oncology
  • Complementary and alternative medicine

Cite this

Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota. / Frankel, Arthur E; Deshmukh, Sachin; Reddy, Amit; Lightcap, John; Hayes, Maureen; McClellan, Steven; Singh, Seema; Rabideau, Brooks; Glover, T. Grant; Roberts, Bruce; Koh, Andrew.

In: Integrative Cancer Therapies, Vol. 18, 01.04.2019.

Research output: Contribution to journalReview article

Frankel, AE, Deshmukh, S, Reddy, A, Lightcap, J, Hayes, M, McClellan, S, Singh, S, Rabideau, B, Glover, TG, Roberts, B & Koh, A 2019, 'Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota', Integrative Cancer Therapies, vol. 18. https://doi.org/10.1177/1534735419846379
Frankel, Arthur E ; Deshmukh, Sachin ; Reddy, Amit ; Lightcap, John ; Hayes, Maureen ; McClellan, Steven ; Singh, Seema ; Rabideau, Brooks ; Glover, T. Grant ; Roberts, Bruce ; Koh, Andrew. / Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota. In: Integrative Cancer Therapies. 2019 ; Vol. 18.
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