TY - JOUR
T1 - Cancer of the esophagus
AU - Spechler, S. J.
PY - 1995
Y1 - 1995
N2 - A number of recent reports have provided insight into the pathogenesis, staging, and treatment of esophageal cancer. Human papillomavirus can be carcinogenic in squamous epithelium, and more than 20% of esophageal squamous cell tumors have been found to be infected with the virus. The frequency of adenocarcinoma of the esophagus and esophagogastric junction continues to rise in the United States and Europe. Recent reports suggest that these tumors may arise from short, unrecognized segments of intestinal metaplasia that occur commonly at the esophagogastric junction. New studies confirm that endosonography is the best available imaging technique for assessing the depth of tumor invasion and the presence of regional lymph nodes. Several investigations have focused on chemoradiotherapy, a promising, but toxic, new treatment for esophageal cancer, and on biomarkers that might be used to tailor therapy for affected patients. Although cancers of the thoracic esophagus that involve the cervical lymph nodes traditionally have been considered incurable, two recent studies have challenged this contention.
AB - A number of recent reports have provided insight into the pathogenesis, staging, and treatment of esophageal cancer. Human papillomavirus can be carcinogenic in squamous epithelium, and more than 20% of esophageal squamous cell tumors have been found to be infected with the virus. The frequency of adenocarcinoma of the esophagus and esophagogastric junction continues to rise in the United States and Europe. Recent reports suggest that these tumors may arise from short, unrecognized segments of intestinal metaplasia that occur commonly at the esophagogastric junction. New studies confirm that endosonography is the best available imaging technique for assessing the depth of tumor invasion and the presence of regional lymph nodes. Several investigations have focused on chemoradiotherapy, a promising, but toxic, new treatment for esophageal cancer, and on biomarkers that might be used to tailor therapy for affected patients. Although cancers of the thoracic esophagus that involve the cervical lymph nodes traditionally have been considered incurable, two recent studies have challenged this contention.
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U2 - 10.1097/00001574-199507000-00014
DO - 10.1097/00001574-199507000-00014
M3 - Review article
AN - SCOPUS:0028881938
SN - 0267-1379
VL - 11
SP - 366
EP - 371
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 4
ER -