Cancer stem cells in triple-negative breast cancer: A potential target and prognostic marker

Christopher J. O'Conor; Tiffany Chen; Iván González; Dengfeng Cao; Yan Peng

doi:10.2217/bmm-2017-0398

Cancer stem cells in triple-negative breast cancer: A potential target and prognostic marker

Christopher J. O'Conor, Tiffany Chen, Iván González, Dengfeng Cao, Yan Peng

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44 ⁺ /CD24 ^- and ALDH1 ⁺ breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC. This review highlights the current understanding of breast cancer stem cells in TNBC, with focus on CD44 ⁺ /CD24 ^- and ALDH1 ⁺ breast cancer stem cells. It is our hope that this work provides insight into the potential role of cancer stem cells in the prognostication and therapeutic targeting of TNBC.

Original language	English (US)
Pages (from-to)	813-820
Number of pages	8
Journal	Biomarkers in Medicine
Volume	12
Issue number	7
DOIs	https://doi.org/10.2217/bmm-2017-0398
State	Published - Jul 2018

Keywords

biomarkers
breast cancer
cancer stem cells
triple-negative breast cancer

ASJC Scopus subject areas

Drug Discovery
Clinical Biochemistry
Biochemistry, medical

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title = "Cancer stem cells in triple-negative breast cancer: A potential target and prognostic marker",

abstract = " Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44 + /CD24 - and ALDH1 + breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC. This review highlights the current understanding of breast cancer stem cells in TNBC, with focus on CD44 + /CD24 - and ALDH1 + breast cancer stem cells. It is our hope that this work provides insight into the potential role of cancer stem cells in the prognostication and therapeutic targeting of TNBC.",

keywords = "biomarkers, breast cancer, cancer stem cells, triple-negative breast cancer",

author = "O'Conor, {Christopher J.} and Tiffany Chen and Iv{\'a}n Gonz{\'a}lez and Dengfeng Cao and Yan Peng",

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year = "2018",

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doi = "10.2217/bmm-2017-0398",

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T2 - A potential target and prognostic marker

AU - O'Conor, Christopher J.

AU - Chen, Tiffany

AU - González, Iván

AU - Cao, Dengfeng

AU - Peng, Yan

PY - 2018/7

Y1 - 2018/7

N2 - Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44 + /CD24 - and ALDH1 + breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC. This review highlights the current understanding of breast cancer stem cells in TNBC, with focus on CD44 + /CD24 - and ALDH1 + breast cancer stem cells. It is our hope that this work provides insight into the potential role of cancer stem cells in the prognostication and therapeutic targeting of TNBC.

AB - Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44 + /CD24 - and ALDH1 + breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. There is new evidence to support the evaluation of cancer stem cells in TNBC for diagnostic purposes. Targeting cancer stem cells may also be a promising, novel strategy for the treatment of TNBC. This review highlights the current understanding of breast cancer stem cells in TNBC, with focus on CD44 + /CD24 - and ALDH1 + breast cancer stem cells. It is our hope that this work provides insight into the potential role of cancer stem cells in the prognostication and therapeutic targeting of TNBC.

KW - biomarkers

KW - breast cancer

KW - cancer stem cells

KW - triple-negative breast cancer

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Cancer stem cells in triple-negative breast cancer: A potential target and prognostic marker

Abstract

Keywords

ASJC Scopus subject areas

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