Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1)

Joke Beuten, Jonathan A L Gelfond, Duangjai Piwkham, Brad H. Pollock, Naomi J. Winick, Anderson B. Collier, Gail E. Tomlinson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 genes were significantly associated with ALL risk at the P < 0.05 level. After correction for multiple testing, rs442264 within the LIM domain only 1 (LMO1) gene at 11p15 remained significant [odds ratio (OR) = 1.90, P= 3× 10-5]. In addition, a major haplotype within LMO1 comprising 14 SNPs with individual risk associations was found to significantly increase ALL risk (OR 5 1.79, P 5 0.0006). A stratified analysis on subtype indicated that risk associations of LMO1 variants are significant in children with precursor B-cell leukemia. These data show that genetic variants within LMO1 are associated with ALL and identify this gene as a strong candidate for precursor B-cell leukemogenesis.

Original languageEnglish (US)
Pages (from-to)1349-1353
Number of pages5
JournalCarcinogenesis
Volume32
Issue number9
DOIs
StatePublished - Sep 9 2011

ASJC Scopus subject areas

  • Cancer Research

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    Beuten, J., Gelfond, J. A. L., Piwkham, D., Pollock, B. H., Winick, N. J., Collier, A. B., & Tomlinson, G. E. (2011). Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1). Carcinogenesis, 32(9), 1349-1353. https://doi.org/10.1093/carcin/bgr091