Canine epidermal langerhans cells express α and γ but not β chains of high-affinity IgE receptor

M. Bonkobara, F. Miyake, H. Yagihara, O. Yamada, D. Azakami, T. Washizu, Ponciano D Cruz, Kiyoshi Ariizumi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Epidermal Langerhans cells (LC) express a high-affinity receptor for IgE (FcεRI), consisting of two chains (α and γ chains) in humans that allows LC to perform Fc receptor-mediated uptake of allergens. We found that canine LC express α and β chains but not β chain of FcεRI, identical to human but not to mouse LC, which do not express functional FcεRI (only γ chain is expressed). This finding indicates that canine LC have FcεRI-mediated function similar to or identical to human LC, raising the possibility that canine species provides a better model than mouse to understand the pathogenesis of human atopic dermatitis and investigate the therapeutic effect of drugs.

Original languageEnglish (US)
Pages (from-to)499-505
Number of pages7
JournalVeterinary Research Communications
Volume29
Issue number6
DOIs
StatePublished - Aug 2005

Fingerprint

Langerhans cells
IgE Receptors
Langerhans Cells
Canidae
receptors
dogs
atopic dermatitis
Fc Receptors
Therapeutic Uses
Atopic Dermatitis
allergens
Allergens
pathogenesis
animal models
drugs
therapeutics
mice
Pharmaceutical Preparations

Keywords

  • α chain
  • β chain
  • γ chain
  • Canine
  • Gene expression
  • High-affinity IgE receptor
  • Langerhans cells

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Canine epidermal langerhans cells express α and γ but not β chains of high-affinity IgE receptor. / Bonkobara, M.; Miyake, F.; Yagihara, H.; Yamada, O.; Azakami, D.; Washizu, T.; Cruz, Ponciano D; Ariizumi, Kiyoshi.

In: Veterinary Research Communications, Vol. 29, No. 6, 08.2005, p. 499-505.

Research output: Contribution to journalArticle

Bonkobara, M. ; Miyake, F. ; Yagihara, H. ; Yamada, O. ; Azakami, D. ; Washizu, T. ; Cruz, Ponciano D ; Ariizumi, Kiyoshi. / Canine epidermal langerhans cells express α and γ but not β chains of high-affinity IgE receptor. In: Veterinary Research Communications. 2005 ; Vol. 29, No. 6. pp. 499-505.
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AU - Azakami, D.

AU - Washizu, T.

AU - Cruz, Ponciano D

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