Canine epidermal langerhans cells express α and γ but not β chains of high-affinity IgE receptor

M. Bonkobara, F. Miyake, H. Yagihara, O. Yamada, D. Azakami, T. Washizu, Ponciano D Cruz, Kiyoshi Ariizumi

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Epidermal Langerhans cells (LC) express a high-affinity receptor for IgE (FcεRI), consisting of two chains (α and γ chains) in humans that allows LC to perform Fc receptor-mediated uptake of allergens. We found that canine LC express α and β chains but not β chain of FcεRI, identical to human but not to mouse LC, which do not express functional FcεRI (only γ chain is expressed). This finding indicates that canine LC have FcεRI-mediated function similar to or identical to human LC, raising the possibility that canine species provides a better model than mouse to understand the pathogenesis of human atopic dermatitis and investigate the therapeutic effect of drugs.

Original languageEnglish (US)
Pages (from-to)499-505
Number of pages7
JournalVeterinary Research Communications
Volume29
Issue number6
DOIs
StatePublished - Aug 1 2005

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Keywords

  • Canine
  • Gene expression
  • High-affinity IgE receptor
  • Langerhans cells
  • α chain
  • β chain
  • γ chain

ASJC Scopus subject areas

  • veterinary(all)

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