TY - JOUR
T1 - Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer
AU - Suchors, Chamey
AU - Kim, James
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/8
Y1 - 2022/8
N2 - The Hedgehog signaling pathway is one of the fundamental pathways required for development and regulation of postnatal regeneration in a variety of tissues. The pathway has also been associated with cancers since the identification of a mutation in one of its components, PTCH, as the cause of Basal Cell Nevus Syndrome, which is associated with several cancers. Our understanding of the pathway in tumorigenesis has expanded greatly since that initial discovery over two decades ago. The pathway has tumor-suppressive and oncogenic functions depending on the context of the cancer. Furthermore, noncanonical activation of GLI transcription factors has been reported in a number of tumor types. Here, we review the roles of canonical Hedgehog signaling pathway and noncanonical GLI activation in cancers, particularly epithelial cancers, and discuss an emerging concept of the distinct outcomes that these modes have on cancer initiation and progression.
AB - The Hedgehog signaling pathway is one of the fundamental pathways required for development and regulation of postnatal regeneration in a variety of tissues. The pathway has also been associated with cancers since the identification of a mutation in one of its components, PTCH, as the cause of Basal Cell Nevus Syndrome, which is associated with several cancers. Our understanding of the pathway in tumorigenesis has expanded greatly since that initial discovery over two decades ago. The pathway has tumor-suppressive and oncogenic functions depending on the context of the cancer. Furthermore, noncanonical activation of GLI transcription factors has been reported in a number of tumor types. Here, we review the roles of canonical Hedgehog signaling pathway and noncanonical GLI activation in cancers, particularly epithelial cancers, and discuss an emerging concept of the distinct outcomes that these modes have on cancer initiation and progression.
KW - Hedgehog signaling pathway
KW - cancer
KW - noncanonical GLI activation
UR - http://www.scopus.com/inward/record.url?scp=85137127380&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137127380&partnerID=8YFLogxK
U2 - 10.3390/cells11162523
DO - 10.3390/cells11162523
M3 - Review article
C2 - 36010600
AN - SCOPUS:85137127380
SN - 2073-4409
VL - 11
JO - Cells
JF - Cells
IS - 16
M1 - 2523
ER -