Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer

Chamey Suchors, James Kim

Research output: Contribution to journalReview articlepeer-review

Abstract

The Hedgehog signaling pathway is one of the fundamental pathways required for development and regulation of postnatal regeneration in a variety of tissues. The pathway has also been associated with cancers since the identification of a mutation in one of its components, PTCH, as the cause of Basal Cell Nevus Syndrome, which is associated with several cancers. Our understanding of the pathway in tumorigenesis has expanded greatly since that initial discovery over two decades ago. The pathway has tumor-suppressive and oncogenic functions depending on the context of the cancer. Furthermore, noncanonical activation of GLI transcription factors has been reported in a number of tumor types. Here, we review the roles of canonical Hedgehog signaling pathway and noncanonical GLI activation in cancers, particularly epithelial cancers, and discuss an emerging concept of the distinct outcomes that these modes have on cancer initiation and progression.

Original languageEnglish (US)
Article number2523
JournalCells
Volume11
Issue number16
DOIs
StatePublished - Aug 2022

Keywords

  • cancer
  • Hedgehog signaling pathway
  • noncanonical GLI activation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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