Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature

Jan M. Stenman, Jay Rajagopal, Thomas J. Carroll, Makoto Ishibashi, Jill McMahon, Andrew P. McMahon

Research output: Contribution to journalArticle

355 Scopus citations

Abstract

Every organ depends on blood vessels for oxygen and nutrients, but the vasculature associated with individual organs can be structurally and molecularly diverse. The central nervous system (CNS) vasculature consists of a tightly sealed endothelium that forms the blood-brain barrier, whereas blood vessels of other organs are more porous. Wnt7a and Wnt7b encode two Wnt ligands produced by the neuroepithelium of the developing CNS coincident with vascular invasion. Using genetic mouse models, we found that these ligands directly target the vascular endothelium and that the CNS uses the canonical Wnt signaling pathway to promote formation and CNS-specific differentiation of the organ's vasculature.

Original languageEnglish (US)
Pages (from-to)1247-1250
Number of pages4
JournalScience
Volume322
Issue number5905
DOIs
StatePublished - Nov 21 2008

ASJC Scopus subject areas

  • General

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    Stenman, J. M., Rajagopal, J., Carroll, T. J., Ishibashi, M., McMahon, J., & McMahon, A. P. (2008). Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science, 322(5905), 1247-1250. https://doi.org/10.1126/science.1164594