Capacity-speed relationships in prefrontal cortex

Vivek Prabhakaran, Bart Rypma, Nandakumar S. Narayanan, Timothy B. Meier, Benjamin P. Austin, Veena A. Nair, Lin Naing, Lisa E. Thomas, John D E Gabrieli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Working memory (WM) capacity and WM processing speed are simple cognitive measures that underlie human performance in complex processes such as reasoning and language comprehension. These cognitive measures have shown to be interrelated in behavioral studies, yet the neural mechanism behind this interdependence has not been elucidated. We have carried out two functional MRI studies to separately identify brain regions involved in capacity and speed. Experiment 1, using a block-design WM verbal task, identified increased WM capacity with increased activity in right prefrontal regions, and Experiment 2, using a single-trial WM verbal task, identified increased WM processing speed with increased activity in similar regions. Our results suggest that right prefrontal areas may be a common region interlinking these two cognitive measures. Moreover, an overlap analysis with regions associated with binding or chunking suggest that this strategic memory consolidation process may be the mechanism interlinking WM capacity and WM speed.

Original languageEnglish (US)
Article numbere27504
JournalPLoS One
Volume6
Issue number11
DOIs
StatePublished - Nov 23 2011

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Prefrontal Cortex
Short-Term Memory
Data storage equipment
prefrontal cortex
Processing
Consolidation
Language
Brain
Magnetic Resonance Imaging
Experiments
brain

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Prabhakaran, V., Rypma, B., Narayanan, N. S., Meier, T. B., Austin, B. P., Nair, V. A., ... Gabrieli, J. D. E. (2011). Capacity-speed relationships in prefrontal cortex. PLoS One, 6(11), [e27504]. https://doi.org/10.1371/journal.pone.0027504

Capacity-speed relationships in prefrontal cortex. / Prabhakaran, Vivek; Rypma, Bart; Narayanan, Nandakumar S.; Meier, Timothy B.; Austin, Benjamin P.; Nair, Veena A.; Naing, Lin; Thomas, Lisa E.; Gabrieli, John D E.

In: PLoS One, Vol. 6, No. 11, e27504, 23.11.2011.

Research output: Contribution to journalArticle

Prabhakaran, V, Rypma, B, Narayanan, NS, Meier, TB, Austin, BP, Nair, VA, Naing, L, Thomas, LE & Gabrieli, JDE 2011, 'Capacity-speed relationships in prefrontal cortex', PLoS One, vol. 6, no. 11, e27504. https://doi.org/10.1371/journal.pone.0027504
Prabhakaran V, Rypma B, Narayanan NS, Meier TB, Austin BP, Nair VA et al. Capacity-speed relationships in prefrontal cortex. PLoS One. 2011 Nov 23;6(11). e27504. https://doi.org/10.1371/journal.pone.0027504
Prabhakaran, Vivek ; Rypma, Bart ; Narayanan, Nandakumar S. ; Meier, Timothy B. ; Austin, Benjamin P. ; Nair, Veena A. ; Naing, Lin ; Thomas, Lisa E. ; Gabrieli, John D E. / Capacity-speed relationships in prefrontal cortex. In: PLoS One. 2011 ; Vol. 6, No. 11.
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