Abstract
Background: Patients with advanced Hodgkin's disease failing to achieve complete remission with chemotherapy or developing disease progression within 1 year have a poor prognosis with salvage chemotherapy.Patients and methods: Twenty-five patients fulfilling the above criteria after failing treatment with ChlVPP (chloram-bucil, vinblastine, procarbazine and prednisolone) or its variant were treated with a new salvage regimen CAPE/PALE (cyclophosphamide, adriamycin, prednisolone, etoposideand lomustine), given for 6 courses at three weekly intervals.Results: Thirteen of the 25 patients (52%) achieved complete remission. After a minimum foliow-up period of 38 months five of these patients remained free from disease progression. This regimen was very well tolerated.Conclusions: CAPE/PALE produces results comparable to other salvage regimens in Hodgkin's disease. New strategies are however required for this patient group.
Original language | English (US) |
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Pages (from-to) | 857-860 |
Number of pages | 4 |
Journal | Annals of Oncology |
Volume | 4 |
Issue number | 10 |
DOIs | |
State | Published - Dec 1993 |
Externally published | Yes |
Keywords
- Chemotherapy
- Hodgkin's
- Salvage
ASJC Scopus subject areas
- Hematology
- Oncology