Background: Patients with advanced Hodgkin's disease failing to achieve complete remission with chemotherapy or developing disease progression within 1 year have a poor prognosis with salvage chemotherapy.Patients and methods: Twenty-five patients fulfilling the above criteria after failing treatment with ChlVPP (chloram-bucil, vinblastine, procarbazine and prednisolone) or its variant were treated with a new salvage regimen CAPE/PALE (cyclophosphamide, adriamycin, prednisolone, etoposideand lomustine), given for 6 courses at three weekly intervals.Results: Thirteen of the 25 patients (52%) achieved complete remission. After a minimum foliow-up period of 38 months five of these patients remained free from disease progression. This regimen was very well tolerated.Conclusions: CAPE/PALE produces results comparable to other salvage regimens in Hodgkin's disease. New strategies are however required for this patient group.
|Original language||English (US)|
|Number of pages||4|
|Journal||Annals of Oncology|
|State||Published - Dec 1993|
ASJC Scopus subject areas