Carbapenem-hydrolyzing gram-negative bacteria: Current options for treatment and review of drugs in development

Foad I. Abandeh, Mark E. Drew, Madhuri M. Sopirala

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Multidrug resistant gram-negative bacteria are an increasing therapeutic challenge. The beta-lactamases are a group of enzymes that confer resistance to the beta-lactam antibiotics. The carbapenems have been in wide use to treat beta-lactamase producing, multidrug resistant gram-negative bacterial infections. However, the emergence of carbapenemases, enzymes capable of hydrolyzing the carbapenems, has limited our therapeutic options. In the recent years, there has been some development in the discovery of new agents such as boronic acid derivatives, ME1071 and Ca-EDTA that may enhance the activity of existing antibiotics, CTC-96 which reverses antibiotic resistance and polymyxin derivatives with decreased renal toxicity. While global efforts towards new drug development should continue, appropriate use of currently available antibiotics is equally important. In this review, we will discuss the general characteristics of carbapenemases, recent patents with drugs under development and current treatment options.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalRecent Patents on Anti-Infective Drug Discovery
Volume7
Issue number1
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Keywords

  • Beta-lactamases
  • Carbapenemases
  • Gram-negative bacteria
  • Multidrug resistant
  • Novel agents
  • Patent

ASJC Scopus subject areas

  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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