Bacteriologic and clinical cure with carbenicillin was obtained in the majority of 17 patients with serious, life-threatening, or chronic infections due to Pseudomonas that had been resistant to other therapy. Four episodes of septicemia and 1 case of abscesses due to Pseudomonas were cured in children with leukemia. Three patients with chronic mastoiditis were cured by a combination of therapy with carbenicillin and mastoidectomy. Bacteriologic response was observed in 2 other patients in whom mastoidectomy was deferred, but relapse or reinfection ensued. Chronic infection of the urinary tract due to Pseudomonas was eliminated in 2 patients; a third patient with neurogenic bladder and ileal pouch responded to 2 courses of carbenicillin but relapsed on both occasions when the drug was withdrawn. Carbenicillin cured infections with Pseudomonas in a premature infant with suppurative arthritis of the hip, in a neonatal infant with pneumonia complicating tetanus, and in a child with peritonitis. No bacteriologic response to therapy occurred in a child with osteomyelitis or in 2 children with cystic fibrosis.No serious toxic effects were encountered. Serum and urine inhibition titers showed reasonably good correlation with the concentrations of antibiotic in these fluids. This simple test might beuseful as a rough guide to adequate dosage in places in which laboratory facilities for determination of antibiotic concentrations are not available.
|Original language||English (US)|
|Journal||Journal of Infectious Diseases|
|State||Published - Sep 1970|
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases