Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a "mixed meal" in late pregnancy

Boyd E. Metzger, Roger H Unger, Norbert Freinkel

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Gestational influences upon the changes in circulating glucose, amino acids, insulin, and glucagon after the ingestion of a "mixed meal" containing carbohydrate (50 g), protein (25 g), and fat (10 g) were examined. Nine subjects were tested during weeks 30-40 of gestation and again 6-8 wk postpartum. The "mixed meal" elicited greater and more prolonged increases in plasma glucose antepartum, whereas the increments in total serum amino acids were blunted at all time points. In the face of greater glycemic but lesser aminogenic stimulation, the integrated increase in plasma insulin was 60% greater antepartum than post partum, whereas the increment in glucagon was not significantly altered. Thus, integrated insulin/glucagon response was increased during antepartum studies. The insulin preponderance following alimentary challenge with mixed nutrients would suggest that the anabolism of ingested amino acids is "facilitated" during late human pregnancy.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalMetabolism
Volume26
Issue number2
DOIs
StatePublished - 1977

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Carbohydrate Metabolism
Glucagon
Meals
Insulin
Amino Acids
Glucose
Pregnancy
Postpartum Period
Eating
Fats
Carbohydrates
Food
Serum
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a "mixed meal" in late pregnancy. / Metzger, Boyd E.; Unger, Roger H; Freinkel, Norbert.

In: Metabolism, Vol. 26, No. 2, 1977, p. 151-156.

Research output: Contribution to journalArticle

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